Isolation of Putative Biosynthetic Intermediates of Prenylated Indole Alkaloids from a Thermophilic Fungus Talaromyces thermophilus

被引：50

作者：

Chu, Yan-Sheng

Niu, Xue-Mei ^{[1
]}

Wang, Yan-Li

Guo, Ji-Peng

Pan, Wen-Zheng

Huang, Xiao-Wei

Zhang, Ke-Qin

机构：

[1] Yunnan Univ, Minist Educ, Lab Conservat & Utilizat Bioresources, Kunming 650091, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 19期

基金：

中国国家自然科学基金;

关键词：

MARINE-DERIVED FUNGUS; BIOMIMETIC TOTAL-SYNTHESIS; STEPHACIDIN-A; ASPERGILLUS; PARAHERQUAMIDES; TRANSFERASES; REVERSE; CONCISE;

D O I：

10.1021/ol101817g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The putative key biosynthetic intermediates of prenylated indole alkaloids have long been proposed but never isolated. Two such alkaloids, named talathermophilins A and B (1 and 2), were isolated from a thermophilic fungus Talaromyces thermophilus strain YM1-3 and were identified by NMR and MS spectroscopic analyses. The ratio of 1 and 2 in the culture broths was unexpectedly rather constant (about 2:3), which even remained unchanged despite the addition of exogenous 1 or 2, suggesting that talathermophilins might be of special function for the extremophilic fungus.

引用

收藏

页码：4356 / 4359

页数：4

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