Asymmetric synthesis of an isoxazolidine nucleoside analog of thymine polyoxin C

被引：24

作者：

Merino, P ^{[1
]}

Franco, S ^{[1
]}

Merchan, FL ^{[1
]}

Tejero, T ^{[1
]}

机构：

[1] Univ Zaragoza, Dept Quim Organ, Fac Ciencias, ICMA,CSIC, Zaragoza, Aragon, Spain

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期

关键词：

nitrones; nucleosides; amino acids and derivatives; isoxazolidines;

D O I：

10.1016/S0040-4039(98)01323-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of an isoxazolidine amino acid nucleoside analog is reported. The key step of the synthesis is the stereoselective nucleophilic addition of a silyl ketene acetal to the N-benzyl nitrone derived from N,O-isopropylidene-L-serinal. The overall yield from the starting nitrone was 16.4% (10 steps). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6411 / 6414

页数：4

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