Enantio- and diastereoselective synthesis of 4′-α-substituted carbocyclic nucleosides

被引：19

作者：

Kato, K

Suzuki, H

Tanaka, H

Miyasaka, T

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 274, Japan

[2] Showa Univ, Sch Pharmaceut Sci, Shinagawa Ku, Tokyo 142, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(98)00065-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantio-and diastereoselective synthesis of 4-alpha-alkylcarbovir derivatives 5 were achieved based on Sakai's asymmetric alkylation of beta-keto esters. The key carbocyclic intermediate 14 was synthesized from 8 via an eleven-step sequence. Coupling of 14 with 2-amino-6-chloropurine followed by desilylation and subsequent hydrolysis gave the target compounds 5 in moderate yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：911 / 914

页数：4

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