Fungal allergens

被引：50

作者：

Kurup, VP ^{[1
]}

机构：

[1] Med Coll Wisconsin, VA Med Ctr, Res Serv 151I, Milwaukee, WI 53295 USA

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2003年 / 3卷 / 05期

关键词：

D O I：

10.1007/s11882-003-0078-6

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Many fungi are capable of causing IgE-mediated hypersensitivity in humans. However, the most predominant fungi implicated in allergy belong to the general Aspergillus, Alternaria, Cladosporium, and Penicillium. Pure and relevant allergens are essential for diagnosis as well as for understanding the immunopathogenesis of the disease. Until recently, pure and standardizable antigens from fungi were not available. In recent years, many recombinant allergens have been produced by molecular cloning. Using these allergens novel methods are being developed to improve diagnosis of mold-induced allergy. By understanding the immunopathogenesis of allergens new avenues might open up leading to improved patient care including immunotherapy and vaccination. This review covers the current status of fungal allergens, their role in reliable immunodiagnosis, and their probable use in immunotherapy and vaccination.

引用

页码：416 / 423

页数：8

共 67 条

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