Structures of trihydroxynaphthalene reductase-fungicide complexes: Implications for structure-based design and catalysis

被引：34

作者：

Liao, DI

Basarab, GS

Gatenby, AA

Valent, B

Jordan, DB ^{[1
]}

机构：

[1] DuPont Cent Res & Dev, Wilmington, DE 19880 USA

[2] DuPont Agr Prod, Wilmington, DE 19880 USA

[3] DuPont Pharmaceut Co, Expt Stn, Wilmington, DE 19880 USA

来源：

STRUCTURE | 2001年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0969-2126(00)00548-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Trihydroxynaphthalene reductase catalyzes two intermediate steps in the fungal melanin biosynthetic pathway. The enzyme, a typical short-chain dehydrogenase, is the biochemical target of three commercial fungicides. The fungicides bind preferentially to the NADPH form of the enzyme.

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页码：19 / 27

页数：9

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