The regulation of AMPA receptor-binding sites

被引:13
作者
Dev, KK [1 ]
Henley, JM [1 ]
机构
[1] Univ Bristol, Sch Med, Dept Anat, Bristol BS8 1TD, Avon, England
基金
英国惠康基金;
关键词
AMPA; glutamate receptors; regulation; radiation inactivation; solubilization; thiol reagents; potassium thiocyanate; phospholipase A(2);
D O I
10.1007/BF02802023
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A wide variety of mechanisms have been identified that can regulate the alpha-amino-3-hydroxy-5-methylisoxazole-;l-propionate (AMPA)-receptor complex. Modulation has been shown to occur at the nucleic acid level via RNA editing and alternative splicing. At the posttranslational level, processes such as phosphorylation, glycosylation, chemical modification of reactive groups on the receptor proteins, interaction with a putative receptor-associated modulatory protein, and changes in the lipid environment have been reported to regulate receptor binding and function. In this review we discuss general aspects of the cell biology, pharmacology, and function of AMPA receptors. In particular, we focus on some factors shown to modulate agonist binding and discuss possible molecular mechanisms underlying the regulation observed.
引用
收藏
页码:33 / 58
页数:26
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