DNA replication origins:: from sequence specificity to epigenetics

被引：92

作者：

Méchali, M ^{[1
]}

机构：

[1] CNRS, Inst Human Genet, F-34396 Montpellier, France

来源：

NATURE REVIEWS GENETICS | 2001年 / 2卷 / 08期

关键词：

D O I：

10.1038/35084598

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Site-specific initiation of DNA replication is a conserved function in all organisms. In Escherichia coli and Saccharomyces cerevisiae. DNA replication origins are sequence specific, but in multicellular organisms, origins are not so clearly defined. In this article, I present a model of origin specification by epigenetic mechanisms that allows the establishment of stable chromatin domains, which are characterized by autonomous replication. According to this model, origins of DNA replication help to establish domains of gene expression for the generation of cell diversity.

引用

收藏

页码：640 / 645

页数：6

相关论文

共 75 条

[1] Start sites of bidirectional DNA synthesis at the human lamin B2 origin [J].

Abdurashidova, G ;

Deganuto, M ;

Klima, R ;

Riva, S ;

Biamonti, G ;

Giacca, M ;

Falaschi, A .

SCIENCE, 2000, 287 (5460) :2023-2026

[2] Genetic dissection of a mammalian replicator in the human β-globin locus [J].

Aladjem, MI ;

Rodewald, LW ;

Kolman, JL ;

Wahl, GM .

SCIENCE, 1998, 281 (5379) :1005-1009

[3] PARTICIPATION OF THE HUMAN BETA-GLOBIN LOCUS-CONTROL REGION IN INITIATION OF DNA-REPLICATION [J].

ALADJEM, MI ;

GROUDINE, M ;

BRODY, LL ;

DIEKEN, ES ;

FOURNIER, REK ;

WAHL, GM ;

EPNER, EM .

SCIENCE, 1995, 270 (5237) :815-819

[4] The Chinese hamster dihydrofolate reductase replication origin beta is active at multiple ectopic chromosomal locations and requires specific DNA sequence elements for activity [J].

Altman, AL ;

Fanning, E .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (04) :1098-1110

[5] YEAST ORIGIN RECOGNITION COMPLEX FUNCTIONS IN TRANSCRIPTION SILENCING AND DNA-REPLICATION [J].

BELL, SP ;

KOBAYASHI, R ;

STILLMAN, B .

SCIENCE, 1993, 262 (5141) :1844-1849

[6] THE MULTIDOMAIN STRUCTURE OF ORC1P REVEALS SIMILARITY TO REGULATORS OF DNA-REPLICATION AND TRANSCRIPTIONAL SILENCING [J].

BELL, SP ;

MITCHELL, J ;

LEBER, J ;

KOBAYASHI, R ;

STILLMAN, B .

CELL, 1995, 83 (04) :563-568

[7] ATP-DEPENDENT RECOGNITION OF EUKARYOTIC ORIGINS OF DNA-REPLICATION BY A MULTIPROTEIN COMPLEX [J].

BELL, SP ;

STILLMAN, B .

NATURE, 1992, 357 (6374) :128-134

[8] Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci [J].

Berezney, R ;

Dubey, DD ;

Huberman, JA .

CHROMOSOMA, 2000, 108 (08) :471-484

[9] UNITS OF DNA-REPLICATION IN DROSOPHILA-MELANOGASTER CHROMOSOMES [J].

BLUMENTH.AB ;

KRIEGSTE.HJ ;

HOGNESS, DS .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1973, 38 :205-223

[10] INITIATION PREFERENCE AT A YEAST ORIGIN OF REPLICATION [J].

BREWER, BJ ;

FANGMAN, WL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) :3418-3422

← 1 2 3 4 5 6 7 8 →