The mode of antifungal action of plant, insect and human defensins

被引：165

作者：

Aerts, A. M. ^{[1
]}

Francois, I. E. J. A. ^{[1
]}

Cammue, B. P. A. ^{[1
]}

Thevissen, K. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, CMPG, B-3001 Heverlee, Belgium

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 13期

关键词：

mode of antifungal action; defensin; plant; insect; human;

D O I：

10.1007/s00018-008-8035-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Defensins are small (similar to 5 kDa), basic, cysteine-rich antimicrobial peptides that fulfill an important role in the innate immunity of their host by combating pathogenic invading micro-organisms. Defensins can inhibit the growth or virulence of microorganisms directly or can do so indirectly by enhancing the host's immune system. Because of their wide distribution in nature, defensins are believed to be ancient molecules with a common ancestor that arose more than a billion years ago. This review summarizes current knowledge concerning the mode of antifungal action of plant, insect and human defensins.

引用

页码：2069 / 2079

页数：11

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