Synthesis and in vitro photodynamic activity of novel galactose-containing phthalocyanines

被引：80

作者：

Lee, PPS

Lo, PC

Chan, EYM

Fong, WP

Ko, WH

Ng, DKP ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Dept Physiol, Shatin, Hong Kong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期

关键词：

D O I：

10.1016/j.tetlet.2004.12.137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of silicon(IV) phthalocyanines with one or two axial acetal-protected galactose substituent(s) have been prepared by typical substitution reactions. The compounds exhibit a high photodynamic activity against HepG2 human hepato-carcinoma cells with IC50 values down to 0.10 muM. (C) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1551 / 1554

页数：4

相关论文

共 30 条

[1] Metal complexes as photo- and radiosensitizers [J].

Ali, H ;

van Lier, JE .

CHEMICAL REVIEWS, 1999, 99 (09) :2379-2450

[2] Current status of phthalocyanines in the photodynamic therapy of cancer [J].

Allen, CM ;

Sharman, WM ;

Van Lier, JE .

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2001, 5 (02) :161-169

[3] New air-stable n-channel organic thin film transistors [J].

Bao, ZA ;

Lovinger, AJ ;

Brown, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (01) :207-208

[4] Highly ordered vacuum-deposited thin films of metallophthalocyanines and their applications in field-effect transistors [J].

Bao, ZN ;

Lovinger, AJ ;

Dodabalapur, A .

ADVANCED MATERIALS, 1997, 9 (01) :42-&

[5] Water-soluble aluminium phthalocyanine-polymer conjugates for PDT: photodynamic activities and pharmacokinetics in tumour-bearing mice [J].

Brasseur, N ;

Ouellet, R ;

La Madeleine, C ;

van Lier, JE .

BRITISH JOURNAL OF CANCER, 1999, 80 (10) :1533-1541

[6] Expression and localization of GLUT1 and GLUT12 in prostate carcinoma [J].

Chandler, JD ;

Williams, ED ;

Slavin, JL ;

Best, JD ;

Rogers, S .

CANCER, 2003, 97 (08) :2035-2042

[7] Efficient synthesis and photodynamic activity of porphyrin-saccharide conjugates: Targeting and incapacitating cancer cells [J].

Chen, X ;

Hui, L ;

Foster, DA ;

Drain, CM .

BIOCHEMISTRY, 2004, 43 (34) :10918-10929

[8] Synthesis and in vitro photodynamic activity of new hexadeca-carboxy phthalocyanines [J].

Choi, CF ;

Tsang, PT ;

Huang, JD ;

Chan, EYM ;

Ko, WH ;

Fong, WP ;

Ng, DKP .

CHEMICAL COMMUNICATIONS, 2004, (19) :2236-2237

[9] Phthalocyanines and related compounds: organic targets for nonlinear optical applications [J].

de la Torre, G ;

Vazquez, P ;

Agullo-Lopez, F ;

Torres, T .

JOURNAL OF MATERIALS CHEMISTRY, 1998, 8 (08) :1671-1683

[10] Photosensitizing properties of a boronated phthalocyanine: studies at the molecular and cellular level [J].

Fabris, C ;

Jori, G ;

Giuntini, F ;

Roncucci, G .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2001, 64 (01) :1-7