T cell receptor-transgenic mouse models for studying cellular immune responses to Salmonella in vivo

被引：10

作者：

Bumann, D ^{[1
]}

机构：

[1] Max Planck Inst Infekt Biol, Mol Biol Abt, D-10117 Berlin, Germany

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2003年 / 37卷 / 2-3期

关键词：

salmonellosis; attenuated live vaccine; T cell induction;

D O I：

10.1016/S0928-8244(03)00064-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cellular immune responses are crucial both for protective immunity against salmonellosis, and for the immunogenicity of oral vaccines based on avirulent live Salmonella as antigen carriers. The crucial early steps of T cell induction are difficult to investigate in conventional animals, but recently developed T cell receptor (TCR)-transgenic models allow visualization of antigen-specific T cells in vivo while they become induced. In this review, the results obtained with four different TCR-transgenic Salmonella infection models are described, and advantages and potential limits of each of the different models are compared. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：105 / 109

页数：5

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