T cell receptor-transgenic mouse models for studying cellular immune responses to Salmonella in vivo

被引：10

作者：

Bumann, D ^{[1
]}

机构：

[1] Max Planck Inst Infekt Biol, Mol Biol Abt, D-10117 Berlin, Germany

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2003年 / 37卷 / 2-3期

关键词：

salmonellosis; attenuated live vaccine; T cell induction;

D O I：

10.1016/S0928-8244(03)00064-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cellular immune responses are crucial both for protective immunity against salmonellosis, and for the immunogenicity of oral vaccines based on avirulent live Salmonella as antigen carriers. The crucial early steps of T cell induction are difficult to investigate in conventional animals, but recently developed T cell receptor (TCR)-transgenic models allow visualization of antigen-specific T cells in vivo while they become induced. In this review, the results obtained with four different TCR-transgenic Salmonella infection models are described, and advantages and potential limits of each of the different models are compared. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：105 / 109

页数：5

共 30 条

[21] Murine salmonellosis studied by confocal Microscopy: Salmonella typhimurium resides intracellularly inside macrophages and exerts a cytotoxic effect on phagocytes in vivo [J].

RichterDahlfors, A ;

Buchan, AMJ ;

Finlay, BB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (04) :569-580

[22] THE PRESENCE OF INTERLEUKIN-4 DURING INVITRO PRIMING DETERMINES THE LYMPHOKINE-PRODUCING POTENTIAL OF CD4+ T-CELLS FROM T-CELL RECEPTOR TRANSGENIC MICE [J].

SEDER, RA ;

PAUL, WE ;

DAVIS, MM ;

FAZEKAS DE ST GROTH, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) :1091-1098

[23] Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells [J].

Sierro, F ;

Dubois, B ;

Coste, A ;

Kaiserlian, D ;

Kraehenbuhl, JP ;

Sirard, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13722-13727

[24] Visualizing T cell competition for peptide/MHC complexes: A specific mechanism to minimize the effect of precursor frequency [J].

Smith, A ;

Wikstrom, ME ;

Fazekas de St Groth, B .

IMMUNITY, 2000, 13 (06) :783-794

[25] Phase 2 clinical trial of attenuated Salmonella enterica serovar Typhi oral live vector vaccine CVD 908-htrA in US volunteers [J].

Tacket, CO ;

Sztein, MB ;

Wasserman, SS ;

Losonsky, G ;

Kotloff, KL ;

Wyant, TL ;

Nataro, JP ;

Edelman, R ;

Perry, J ;

Bedford, P ;

Brown, D ;

Chatfield, S ;

Dougan, G ;

Levine, MM .

INFECTION AND IMMUNITY, 2000, 68 (03) :1196-1201

[26] INDUCTION OF A CELLULAR IMMUNE-RESPONSE TO A DEFINED T-CELL EPITOPE AS AN INSERT IN THE FLAGELLIN OF A LIVE VACCINE STRAIN OF SALMONELLA [J].

VERMA, NK ;

ZIEGLER, HK ;

STOCKER, BAD ;

SCHOOLNIK, GK .

VACCINE, 1995, 13 (03) :235-244

[27] Optimization of GFP levels for analyzing Salmonella gene expression during an infection [J].

Wendland, M ;

Bumann, D .

FEBS LETTERS, 2002, 521 (1-3) :105-108

[28] Major histocompatibility complex class I presentation of ovalbumin peptide 257-264 from exogenous sources: Protein context influences the degree of TAP-independent presentation [J].

Wick, MJ ;

Pfeifer, JD .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (11) :2790-2799

[29] In vivo activation of dendritic cells and T cells during Salmonella enterica serovar typhimurium infection [J].

Yrlid, U ;

Svensson, M ;

Håkansson, A ;

Chambers, BJ ;

Ljunggren, HG ;

Wick, MJ .

INFECTION AND IMMUNITY, 2001, 69 (09) :5726-5735

[30] Regulation of the immune response by antigen [J].

Zinkernagel, RM ;

Hengartner, H .

SCIENCE, 2001, 293 (5528) :251-253

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