Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital

被引：211

作者：

Leavitt, Azita

Navon-Venezia, Shiri

Chmelnitsky, Inna

Schwaber, Mitchell J.

Carmeli, Yehuda

机构：

[1] Tel Aviv Sourasky Med Ctr, Div Epidemiol, IL-64239 Tel Aviv, Israel

[2] Tel Aviv Sourasky Med Ctr, Lab Mol Epidemiol & Antibiot Res, IL-64239 Tel Aviv, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 08期

关键词：

D O I：

10.1128/AAC.00299-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the bla(KPC-3) gene, while almost all other clones carried the bla(KPC-2) gene. This rapid dissemination of KPC outside the United States is worrisome.

引用

页码：3026 / 3029

页数：4

共 25 条

[1] Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii
Afzal-Shah, M
Woodford, N
Livermore, DM
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (02) : 583 - 588
[2] Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 β-lactamases in New York City
Bradford, PA
Bratu, S
Urban, C
Visalli, M
Mariano, N
Landman, D
Rahal, JJ
Brooks, S
Cebular, S
Quale, J
[J]. CLINICAL INFECTIOUS DISEASES, 2004, 39 (01) : 55 - 60
[3] Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY:: molecular epidemiology and in vitro activity of polymyxin B and other agents
Bratu, S
Tolaney, P
Karumudi, U
Quale, J
Mooty, M
Nichani, S
Landman, D
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (01) : 128 - 132
[4] Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City -: A new threat to our antibiotic armamentarium
Bratu, S
Landman, D
Haag, R
Recco, R
Eramo, A
Alam, M
Quale, J
[J]. ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (12) : 1430 - 1435
[5] Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York:: Epidemiology and recommendations for detection
Bratu, S
Mooty, M
Nichani, S
Landman, D
Gullans, C
Pettinato, B
Karumudi, U
Tolaney, P
Quale, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (07) : 3018 - 3020
[6] CARMELI Y, 2006, 46 INT C ANT AG CHEM
[7] Molecular characterization of a β-lactamase gene, blaGIM-1, encoding a new subclass of metallo-β-lactamase
Castanheira, M
Toleman, MA
Jones, RN
Schmidt, FJ
Walsh, TR
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (12) : 4654 - 4661
[8] Clinical and Laboratory Standards Institute/NCCLS, 2005, M100S15 CLSINCCLS
[9] DESPHANDE LM, 2006, DRUG RESIST, V12, P223
[10] Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii
Héritier, C
Poirel, L
Aubert, D
Nordmann, P
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) : 268 - 273

← 1 2 3 →