Furan based cyclic Oligopeptides selectively target G-quadruplex

被引：50

作者：

Chakraborty, Tushar Kanti ^{[1
]}

Arora, Amit

Roy, Saumya

Kumar, Niti

Maiti, Souvik

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

[2] Inst Genom & Integrat Biol, Proteom & Struct Biol Unit, Delhi 110007, India

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 23期

关键词：

D O I：

10.1021/jm070619c

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the binding properties of 18- and 24-membered cyclic oligopeptides developed from a novel furan amino acid, 5-(aminomethyl)-2-furancarboxylic acid, to G-quadruplex. Comparative analysis of the binding data of these ligands with G-quadruplex and double-strand DNA shows that 24-membered cyclic peptides are highly selective for telomeric G-quadruplex structures and thus can be used as a scaffold to target quadruplex structures at the genomic level.

引用

页码：5539 / 5542

页数：4

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