The roles of receptor and ligand endocytosis in regulating Notch signaling

被引：261

作者：

Le Borgne, R ^{[1
]}

Bardin, A ^{[1
]}

Schweisguth, F ^{[1
]}

机构：

[1] Ecole Normale Super, CNRS, UMR 8542, F-75230 Paris, France

来源：

DEVELOPMENT | 2005年 / 132卷 / 08期

关键词：

D O I：

10.1242/dev.01789

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N) is the receptor of a conserved signaling pathway that regulates numerous developmental decisions, and the misregulation of N has been linked to various physiological and developmental disorders. The endocytosis of N and its ligands is a key mechanism by which N-mediated cell-cell signaling is developmentally regulated. We review here the recent findings that have highlighted the importance and complexity of this regulation.

引用

页码：1751 / 1762

页数：12

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