Mast cell mediators in tolerance

被引：49

作者：

de Vries, Victor C. ^{[1
,2
]}

Noelle, Randolph J. ^{[1
,2
,3
]}

机构：

[1] Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH USA

[2] Norris Cotton Canc Ctr, Lebanon, NH USA

[3] Kings Coll London, Dept Nephrol & Transplantat, MRC Ctr Transplantat, London, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 05期

关键词：

ALLERGIC INFLAMMATION; DENDRITIC CELLS; TRYPTASE MMCP-6; T-CELLS; SKIN; PROTEASES; IL-10; IRRADIATION; TGF-BETA-1; RESPONSES;

D O I：

10.1016/j.coi.2010.08.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Our knowledge on the function of mast cells (MC) as part of the immune system has expanded from key cells in mediating allergy' to 'tunable regulators of the immune response' Over the past years however a large body of evidence has been presented indicating a more regulatory role for MC in the immune system by both contact dependent and independent mechanisms Considering the vast amount of soluble mediators released by MC it is not surprising that some are involved in the maintenance of peripheral tolerance and the control or even help to resolve ongoing inflammation In this review we will focus on the immunosuppressive function of some of these mediators produced by MC in a wide variety of disease models

引用

页码：643 / 648

页数：6

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