Phytoestrogens in menopausal women: a review of recent findings

被引:7
作者
Dodin, S [1 ]
Blanchet, C
Marc, I
机构
[1] Univ Laval, Dept Obstet & Gynecol, Quebec City, PQ G1K 7P4, Canada
[2] CHUQ, Hop St Francois Assise, Quebec City, PQ G1L 3L5, Canada
来源
M S-MEDECINE SCIENCES | 2003年 / 19卷 / 10期
关键词
D O I
10.1051/medsci/200319101030
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 [基础医学];
摘要
Many women seek alternatives to hormone replacement therapy (HRT). Phytoestrogens are nonsteroidal compounds with estrogenic or antiestrogenic properties. Six of the 16 clinical trials suggest a significant reduction in alleviating symptoms but to a lesser degree than HRT. A meta-analysis showed that phytoestrogens improve lipid profile. The 14 recent clinical trials led, however, to divergent findings. Small clinical trials suggested a protective effect of phytoestrogens on bone metabolism. High concentration of phytoestrogens was associated with a reduction in breast cancer risk in case-control studies.
引用
收藏
页码:1030 / 1038
页数:9
相关论文
共 54 条
[1]
Phyto-oestrogens and cancer [J].
Adlercreutz, H .
LANCET ONCOLOGY, 2002, 3 (06) :364-373
[2]
The effect of dietary soy supplementation on hot flushes [J].
Albertazzi, P ;
Pansini, F ;
Bonaccorsi, G ;
Zanotti, L ;
Forini, E ;
De Aloysio, D .
OBSTETRICS AND GYNECOLOGY, 1998, 91 (01) :6-11
[3]
Alekel DL, 2000, AM J CLIN NUTR, V72, P844
[4]
METAANALYSIS OF THE EFFECTS OF SOY PROTEIN-INTAKE ON SERUM-LIPIDS [J].
ANDERSON, JW ;
JOHNSTONE, BM ;
COOKNEWELL, ME .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (05) :276-282
[5]
Soy and cardiovascular disease: Cholesterol lowering and beyond [J].
Anthony, MS .
JOURNAL OF NUTRITION, 2000, 130 (03) :662S-663S
[6]
Baber R J, 1999, Climacteric, V2, P85, DOI 10.3109/13697139909025571
[7]
DIETARY INTERVENTION STUDY TO ASSESS ESTROGENICITY OF DIETARY SOY AMONG POSTMENOPAUSAL WOMEN [J].
BAIRD, DD ;
UMBACH, DM ;
LANSDELL, L ;
HUGHES, CL ;
SETCHELL, KDR ;
WEINBERG, CR ;
HANEY, AF ;
WILCOX, AJ ;
MCLACHLAN, JA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (05) :1685-1690
[8]
Brzezinski A, 1997, MENOPAUSE, V4, P89
[9]
Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial [J].
Chiechi, LM ;
Secreto, G ;
D'Amore, M ;
Fanelli, M ;
Venturelli, E ;
Cantatore, F ;
Valerio, T ;
Laselva, G ;
Loizzi, P .
MATURITAS, 2002, 42 (04) :295-300
[10]
Inhibition of postmenopausal atherosclerosis progression: A comparison of the effects of conjugated equine estrogens and soy phytoestrogens [J].
Clarkson, TB ;
Anthony, MS ;
Morgan, TM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (01) :41-47