Experimental Inflammatory Bowel Disease: Insights into the Host-Microbiota Dialog

被引：124

作者：

Saleh, Maya ^{[1
]}

Elson, Charles O. ^{[2
]}

机构：

[1] McGill Univ, Dept Med, Montreal, PQ H3G 0B1, Canada

[2] Univ Alabama Birmingham, Dept Med, Div Gastroenterol & Hepatol, Birmingham, AL 35294 USA

来源：

IMMUNITY | 2011年 / 34卷 / 03期

关键词：

REGULATORY T-CELLS; GENOME-WIDE ASSOCIATION; ACTIVE CROHNS-DISEASE; ULCERATIVE-COLITIS; DENDRITIC CELLS; GUT MICROBIOTA; CUTTING EDGE; COLORECTAL-CANCER; BET DEFICIENCY; MICE DEFICIENT;

D O I：

10.1016/j.immuni.2011.03.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammatory bowel disease appears to result from an abnormal host immune response to the intestinal microbiota. Experimental models have allowed the dissection of the complex dialog between the host and its microbiota. Through genetic manipulation of the host genome the immune compartments, cells, molecules, and genes that are critical for maintenance of intestinal homeostasis are being identified. Genetic association studies in humans have identified over 100 susceptibility loci. Although there is remarkable coherence between the experimental model and the human genetic data, a full understanding of the mechanisms involved in genetic susceptibility to IBD and of gene-gene and gene-environmental interactions will require a "next generation" of experimental models.

引用

页码：293 / 302

页数：10

共 113 条

[21] Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity [J].

Clarke, Thomas B. ;

Davis, Kimberly M. ;

Lysenko, Elena S. ;

Zhou, Alice Y. ;

Yu, Yimin ;

Weiser, Jeffrey N. .

NATURE MEDICINE, 2010, 16 (02) :228-U137

[22] A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota [J].

Cong, Yingzi ;

Feng, Ting ;

Fujihashi, Kohtaro ;

Schoeb, Trenton R. ;

Elson, Charles O. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (46) :19256-19261

[23] CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice:: Increased T helper cell type 1 response and ability to transfer disease [J].

Cong, YZ ;

Brandwein, SL ;

McCabe, RP ;

Lazenby, A ;

Birkenmeier, EH ;

Sundberg, JP ;

Elson, CO .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (06) :855-864

[24] NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation [J].

Cooney, Rachel ;

Baker, John ;

Brain, Oliver ;

Danis, Benedicte ;

Pichulik, Tica ;

Allan, Philip ;

Ferguson, David J. P. ;

Campbell, Barry J. ;

Jewell, Derek ;

Simmons, Alison .

NATURE MEDICINE, 2010, 16 (01) :90-U128

[25] Cutting edge:: CD4+CD25+ for intestinal homing can regulatory T cells impaired prevent colitis [J].

Denning, TL ;

Kim, G ;

Kronenberg, M .

JOURNAL OF IMMUNOLOGY, 2005, 174 (12) :7487-7491

[26] DEXTRAN SULFATE SODIUM-INDUCED COLITIS OCCURS IN SEVERE COMBINED IMMUNODEFICIENT MICE [J].

DIELEMAN, LA ;

RIDWAN, BU ;

TENNYSON, GS ;

BEAGLEY, KW ;

BUCY, RP ;

ELSON, CO .

GASTROENTEROLOGY, 1994, 107 (06) :1643-1652

[27] Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases [J].

Dupaul-Chicoine, Jeremy ;

Yeretssian, Garabet ;

Doiron, Karine ;

Bergstrom, Kirk S. B. ;

McIntire, Christian R. ;

LeBlanc, Philippe M. ;

Meunier, Charles ;

Turbide, Claire ;

Gros, Philippe ;

Beauchemin, Nicole ;

Vallance, Bruce A. ;

Saleh, Maya .

IMMUNITY, 2010, 32 (03) :367-378

[28] Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice [J].

Elson, Charles O. ;

Cong, Yingzi ;

Weaver, Casey T. ;

Schoeb, Trenton R. ;

McClanahan, Terrill K. ;

Fick, Robert B. ;

Kastelein, Robert A. .

GASTROENTEROLOGY, 2007, 132 (07) :2359-2370

[29]

Elson CO, 2009, INFLAMM BOWEL DIS, P25

[30] Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci [J].

Franke, Andre ;

McGovern, Dermot P. B. ;

Barrett, Jeffrey C. ;

Wang, Kai ;

Radford-Smith, Graham L. ;

Ahmad, Tariq ;

Lees, Charlie W. ;

Balschun, Tobias ;

Lee, James ;

Roberts, Rebecca ;

Anderson, Carl A. ;

Bis, Joshua C. ;

Bumpstead, Suzanne ;

Ellinghaus, David ;

Festen, Eleonora M. ;

Georges, Michel ;

Green, Todd ;

Haritunians, Talin ;

Jostins, Luke ;

Latiano, Anna ;

Mathew, Christopher G. ;

Montgomery, Grant W. ;

Prescott, Natalie J. ;

Raychaudhuri, Soumya ;

Rotter, Jerome I. ;

Schumm, Philip ;

Sharma, Yashoda ;

Simms, Lisa A. ;

Taylor, Kent D. ;

Whiteman, David ;

Wijmenga, Cisca ;

Baldassano, Robert N. ;

Barclay, Murray ;

Bayless, Theodore M. ;

Brand, Stephan ;

Buening, Carsten ;

Cohen, Albert ;

Colombel, Jean-Frederick ;

Cottone, Mario ;

Stronati, Laura ;

Denson, Ted ;

De Vos, Martine ;

D'Inca, Renata ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Florin, Tim ;

Franchimont, Denis ;

Gearry, Richard ;

Glas, Juergen ;

Van Gossum, Andre .

NATURE GENETICS, 2010, 42 (12) :1118-+

← 1 2 3 4 5 6 7 8 9 10 →