G-quadruplex DNA structures - Variations on a theme

被引:531
作者
Simonsson, T [1 ]
机构
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
关键词
c-myc; G-quartet; G4-DNA; oncogene; telomere; tetraplex;
D O I
10.1515/BC.2001.073
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To be functional, nucleic acids need to adopt particular three-dimensional structures. For a long time DNA was regarded as a rigid and passive molecule with the sole purpose to store genetic information, but experimental data has now accumulated that indicates the full dynamic repertoire of this macromolecule. During the last decade, four-stranded DNA structures known as G-quadruplexes, or DNA tetraplexes, have emerged as a three-dimensional structure of special interest. Motifs for the formation of G-quadruplex DNA structures are widely dispersed in eukaryotic genomes, and are abundant in regions of biological significance, for example, at telomeres, in the promoters of many important genes, and at recombination hotspots, to name but a few in man. Here I explore the plethora of G-quadruplex DNA structures, and discuss their possible biological functions as well as the proteins that interact with them.
引用
收藏
页码:621 / 628
页数:8
相关论文
共 90 条
[81]   SOLUTION STRUCTURE OF A PARALLEL-STRANDED G-QUADRUPLEX DNA [J].
WANG, Y ;
PATEL, DJ .
JOURNAL OF MOLECULAR BIOLOGY, 1993, 234 (04) :1171-1183
[82]   GUANINE RESIDUES IN D(T2AG3) AND D(T2G4) FORM PARALLEL-STRANDED POTASSIUM CATION STABILIZED G-QUADRUPLEXES WITH ANTIGLYCOSIDIC TORSION ANGLES IN SOLUTION [J].
WANG, Y ;
PATEL, DJ .
BIOCHEMISTRY, 1992, 31 (35) :8112-8119
[83]   SOLUTION STRUCTURE OF THE HUMAN TELOMERIC REPEAT D[AG(3)(T(2)AG(3))3] G-TETRAPLEX [J].
WANG, Y ;
PATEL, DJ .
STRUCTURE, 1993, 1 (04) :263-282
[84]   SOLUTION STRUCTURE OF THE TETRAHYMENA TELOMERIC REPEAT D(T(2)G(4))(4) G-TETRAPLEX [J].
WANG, Y ;
PATEL, DJ .
STRUCTURE, 1994, 2 (12) :1141-1156
[85]   SOLUTION STRUCTURE OF THE OXYTRICHA TELOMERIC REPEAT D[G(4)(T(4)G(4))(3)] G-TETRAPLEX [J].
WANG, Y ;
PATEL, DJ .
JOURNAL OF MOLECULAR BIOLOGY, 1995, 251 (01) :76-94
[86]   TRIPLET REPEAT EXPANSION MUTATIONS - THE EXAMPLE OF FRAGILE-X SYNDROME [J].
WARREN, ST ;
ASHLEY, CT .
ANNUAL REVIEW OF NEUROSCIENCE, 1995, 18 :77-99
[87]  
WEISMANSHOMER P, 1993, J BIOL CHEM, V268, P3306
[88]   STABILIZATION OF TETRAHELICAL DNA BY THE QUADRUPLEX DNA-BINDING PROTEIN QUAD [J].
WEISMANSHOMER, P ;
FRY, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 205 (01) :305-311
[89]  
Zimmerman S B, 1975, Biopolymers, V14, P889, DOI 10.1002/bip.1975.360140416
[90]   X-RAY FIBER DIFFRACTION AND MODEL-BUILDING STUDY OF POLYGUANYLIC ACID AND POLYINOSINIC ACID [J].
ZIMMERMAN, SB ;
COHEN, GH ;
DAVIES, DR .
JOURNAL OF MOLECULAR BIOLOGY, 1975, 92 (02) :181-&