Niche regulation of muscle satellite cell self-renewal and differentiation

被引:359
作者
Kuang, Shihuan [1 ]
Gillespie, Mark A. [1 ,2 ]
Rudnicki, Michael A. [1 ,2 ]
机构
[1] Sprott Ctr Stem Cell Res, Ottawa Hlth Res Inst, Regenerat Med Program, Ottawa, ON K1H 8L6, Canada
[2] Univ Ottawa, Fac Med, Dept Cell & Mol Med, Ottawa, ON K1H 8M5, Canada
关键词
D O I
10.1016/j.stem.2007.12.012
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.
引用
收藏
页码:22 / 31
页数:10
相关论文
共 99 条
[1]   Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells [J].
Beauchamp, JR ;
Heslop, L ;
Yu, DSW ;
Tajbakhsh, S ;
Kelly, RG ;
Wernig, A ;
Buckingham, ME ;
Partridge, TA ;
Zammit, PS .
JOURNAL OF CELL BIOLOGY, 2000, 151 (06) :1221-1233
[2]   Restoration of human dystrophin following transplantation of exon-skipping-engineered DMD patient stem cells into dystrophic mice [J].
Benchaouir, Rachid ;
Meregalli, Mirella ;
Farini, Andrea ;
D'Antona, Giuseppe ;
Belicchi, Marzia ;
Goyenvalle, Aurelie ;
Battistelli, Maurizio ;
Bresolin, Nereo ;
Bottinelli, Roberto ;
Garcia, Luis ;
Torrente, Yvan .
CELL STEM CELL, 2007, 1 (06) :646-657
[3]   REGENERATION OF SINGLE SKELETAL-MUSCLE FIBERS INVITRO [J].
BISCHOFF, R .
ANATOMICAL RECORD, 1975, 182 (02) :215-235
[4]   A temporal switch from Notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis [J].
Brack, Andrew S. ;
Conboy, Irina M. ;
Conboy, Michael J. ;
Shen, Jeanne ;
Rando, Thomas A. .
CELL STEM CELL, 2008, 2 (01) :50-59
[5]   Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis [J].
Brack, Andrew S. ;
Conboy, Michael J. ;
Roy, Sudeep ;
Lee, Mark ;
Kuo, Calvin J. ;
Keller, Charles ;
Rando, Thomas A. .
SCIENCE, 2007, 317 (5839) :807-810
[6]   The α7β1 integrin in muscle development and disease [J].
Burkin, DJ ;
Kaufman, SJ .
CELL AND TISSUE RESEARCH, 1999, 296 (01) :183-190
[7]   MUTATION SELECTION AND NATURAL-HISTORY OF CANCER [J].
CAIRNS, J .
NATURE, 1975, 255 (5505) :197-200
[8]  
CARLSON BM, 1989, AM J PHYSIOL, V256, pC1262
[9]   inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis [J].
Carmena, A ;
Murugasu-Oei, B ;
Menon, D ;
Jiménez, F ;
Chia, W .
GENES & DEVELOPMENT, 1998, 12 (03) :304-315
[10]   Cellular and molecular regulation of muscle regeneration [J].
Chargé, SBP ;
Rudnicki, MA .
PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :209-238