Evaluation of BBG2Na in infant macaques:: specific immune responses after vaccination and RSV challenge

被引：37

作者：

de Waal, L

Power, UF

Yüksel, S

van Amerongen, G

Nguyen, TN

Niesters, HGM

de Swart, RL

Osterhaus, ADME

机构：

[1] Erasmus MC, Dept Virol, NL-3000 DR Rotterdam, Netherlands

[2] CIPF, F-74164 St Julien En Genevois, France

来源：

VACCINE | 2004年 / 22卷 / 08期

关键词：

BBG2Na; RSV; immunopathology;

D O I：

10.1016/j.vaccine.2003.10.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have addressed the safety of alum-adsorbed BBG2Na, a recombinant respiratory syncytial virus (RSV) subunit vaccine, in infant macaques. Animals received two vaccinations, and were challenged 4 months later with RSV. In two of four BBG2Na-vaccinated animals, specific IL-13 producing T cells were detected. Upon challenge, low level pulmonary eosinophilia was observed in the same two animals. Although the levels of these responses were substantially lower than those observed in the FI-RSV controls, these data suggest that more extensive studies focusing on immunopathological safety of alum-adsorbed BBG2Na in non-human primates would be required before proceeding to clinical trials in seronegative infants. (C) 2003 Elsevier Ltd. All rights reserved.

引用

收藏

页码：915 / 922

页数：8

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