RNA asymmetric distribution and daughter/mother differentiation in yeast

被引：37

作者：

Darzacq, X ^{[1
]}

Powrie, E ^{[1
]}

Gu, W ^{[1
]}

Singer, RH ^{[1
]}

Zenklusen, D ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2003年 / 6卷 / 06期

关键词：

D O I：

10.1016/j.mib.2003.10.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Active transport and localized translation of the ASH1 mRNA at the bud tip of the budding yeast Saccharomyces cerevisiae is an essential process that is required for the regulation of the mating type switching. ASH1 mRNA localization has been extensively studied over the past few years and the core components of the translocation machinery have been identified. It is composed of four localization elements (zipcodes), within the ASH1 mRNA, and at least three proteins, She1p/Myo4p, She2p and She3p. Whereas the movement of the RNA can be attributed to direct interaction with myosin, the regulation of the RNA expression is less well understood. Recent insights have revealed a role for translation that might have a key function in the regulation of Ash1 protein sorting.

引用

页码：614 / 620

页数：7

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