Expansion of human hematopoietic stem cells for transplantation:: trends and perspectives

被引：34

作者：

Andrade-Zaldivar, Hera ^{[1
]}

Santos, Leticia ^{[1
]}

De Leon Rodriguez, Antonio ^{[1
]}

机构：

[1] Inst Potosino Invest Cient & Tecnol, Div Mol Biol, San Luis Potosi 78216, Mexico

来源：

CYTOTECHNOLOGY | 2008年 / 56卷 / 03期

关键词：

2D-culture; 3D-culture; human cells; leukemia; rotating wall vessel; stirred tank; transplant;

D O I：

10.1007/s10616-008-9144-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Umbilical cord blood transplantation is clinically limited by its low progenitor cell content. Ex vivo expansion has become an alternative to increase the cell dose available for transplants. Expansion has been evaluated in several ways such as static cultures combining growth factors or mimicking the natural microenvironment using co-culture systems. However, static cultures have a small volume capacity and therefore large-scale expansion has been addressed using bioreactors. These and other biotechnological approaches for the expansion of hematopoietic progenitors and their utility to study several aspects of hematopoietic stem cell biology are discussed here.

引用

页码：151 / 160

页数：10

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