Aging and disease as modifiers of efficacy of cell therapy

被引：292

作者：

Dimmeler, Stefanie ^{[1
]}

Leri, Annarosa ^{[2
,3
]}

机构：

[1] Goethe Univ Frankfurt, Dept Internal Med 3, D-60590 Frankfurt, Germany

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

CIRCULATION RESEARCH | 2008年 / 102卷 / 11期

关键词：

angiogenesis; diabetes; stem cells;

D O I：

10.1161/CIRCRESAHA.108.175943

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell therapy is a promising option for treating ischemic diseases and heart failure. Adult stem and progenitor cells from various sources have experimentally been shown to augment the functional recovery after ischemia, and clinical trials have confirmed that autologous cell therapy using bone marrow-derived or circulating blood-derived progenitor cells is safe and provides beneficial effects. However, aging and risk factors for coronary artery disease affect the functional activity of the endogenous stem/progenitor cell pools, thereby at least partially limiting the therapeutic potential of the applied cells. In addition, age and disease affect the tissue environment, in which the cells are infused or injected. The present review article will summarize current evidence for cell impairment during aging and disease but also discuss novel approaches how to reverse the dysfunction of cells or to refresh the target tissue. Pretreatment of cells or the target tissue by small molecules, polymers, growth factors, or a combination thereof may provide useful approaches for enhancement of cell therapy for cardiovascular diseases.

引用

页码：1319 / 1330

页数：12

共 132 条

[1] Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells [J].

Aicher, A ;

Heeschen, C ;

Mildner-Rihm, C ;

Urbich, C ;

Ihling, C ;

Technau-Ihling, K ;

Zeiher, AM ;

Dimmeler, S .

NATURE MEDICINE, 2003, 9 (11) :1370-1376

[2] Low-energy shock wave for enhancing recruitment of endothelial progenitor cells - A new modality to increase efficacy of cell therapy in chronic hind limb ischemia [J].

Aicher, Alexandra ;

Heeschen, Christopher ;

Sasaki, Ken-ichiro ;

Urbich, Carmen ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

CIRCULATION, 2006, 114 (25) :2823-2830

[3] Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role? [J].

Allsopp, RC ;

Weissman, IL .

ONCOGENE, 2002, 21 (21) :3270-3273

[4] Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity [J].

Arking, DE ;

Atzmon, G ;

Arking, A ;

Barzilai, N ;

Dietz, HC .

CIRCULATION RESEARCH, 2005, 96 (04) :412-418

[5] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[6] Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy [J].

Askari, AT ;

Unzek, S ;

Popovic, ZB ;

Goldman, CK ;

Forudi, F ;

Kiedrowski, M ;

Rovner, A ;

Ellis, SG ;

Thomas, JD ;

DiCorleto, PE ;

Topol, EJ ;

Penn, MS .

LANCET, 2003, 362 (9385) :697-703

[7] Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: (TOPCARE-AMI) [J].

Assmus, B ;

Schächinger, V ;

Teupe, C ;

Britten, M ;

Lehmann, R ;

Döbert, N ;

Grünwald, F ;

Aicher, A ;

Urbich, C ;

Martin, H ;

Hoelzer, D ;

Dimmeler, S ;

Zeiher, AM .

CIRCULATION, 2002, 106 (24) :3009-3017

[8]

ASSMUS B, 2007, TOPCARECHD REGISTRY, V100, P1234

[9] Transcoronary transplantation of progenitor cells after myocardial infarction [J].

Assmus, Birgit ;

Honold, Joerg ;

Schaechinger, Volker ;

Britten, Martina B. ;

Fischer-Rasokat, Ulrich ;

Lehmann, Ralf ;

Teupe, Claudius ;

Pistorius, Katrin ;

Martin, Hans ;

Abolmaali, Nasreddin D. ;

Tonn, Torsten ;

Dimmeler, Stefanie ;

Zeiher, Andreas M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (12) :1222-1232

[10] Obese diabetic mouse environment differentially affects primitive and monocytic endothelial cell progenitors [J].

Awad, O ;

Jiao, CH ;

Ma, N ;

Dunnwald, M ;

Schatteman, GC .

STEM CELLS, 2005, 23 (04) :575-583

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