Aging and disease as modifiers of efficacy of cell therapy

被引：292

作者：

Dimmeler, Stefanie ^{[1
]}

Leri, Annarosa ^{[2
,3
]}

机构：

[1] Goethe Univ Frankfurt, Dept Internal Med 3, D-60590 Frankfurt, Germany

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

CIRCULATION RESEARCH | 2008年 / 102卷 / 11期

关键词：

angiogenesis; diabetes; stem cells;

D O I：

10.1161/CIRCRESAHA.108.175943

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell therapy is a promising option for treating ischemic diseases and heart failure. Adult stem and progenitor cells from various sources have experimentally been shown to augment the functional recovery after ischemia, and clinical trials have confirmed that autologous cell therapy using bone marrow-derived or circulating blood-derived progenitor cells is safe and provides beneficial effects. However, aging and risk factors for coronary artery disease affect the functional activity of the endogenous stem/progenitor cell pools, thereby at least partially limiting the therapeutic potential of the applied cells. In addition, age and disease affect the tissue environment, in which the cells are infused or injected. The present review article will summarize current evidence for cell impairment during aging and disease but also discuss novel approaches how to reverse the dysfunction of cells or to refresh the target tissue. Pretreatment of cells or the target tissue by small molecules, polymers, growth factors, or a combination thereof may provide useful approaches for enhancement of cell therapy for cardiovascular diseases.

引用

页码：1319 / 1330

页数：12

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