Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development

被引：39

作者：

Roze, Elise ^{[1
,2
,4
]}

Harris, Polly A. ^{[1
,2
]}

Ball, Gareth ^{[1
,2
]}

Zubiaurre Elorza, Leire ^{[1
,2
,5
]}

Braga, Rodrigo M. ^{[1
,2
]}

Allsop, Joanna M. ^{[1
,2
]}

Merchant, Nazakat ^{[1
,2
,3
]}

Porter, Emma ^{[3
]}

Arichi, Tomoki ^{[1
,2
,3
]}

Edwards, A. David ^{[1
,2
,3
]}

Rutherford, Mary A. ^{[2
,3
]}

Cowan, Frances M. ^{[1
,2
,3
]}

Counsell, Serena J. ^{[1
,2
]}

机构：

[1] Hammersmith Hosp, Robert Steiner MR Unit, MRC Clin Sci Ctr, London W12 0HS, England

[2] Univ London Imperial Coll Sci Technol & Med, Ctr Developing Brain, London W12 0NN, England

[3] Imperial Coll Healthcare NHS Trust, Div Neonatol, London W12 0HS, England

[4] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Div Neonatol, NL-9713 AV Groningen, Netherlands

[5] Univ Barcelona, Fac Med, Dept Psychiat & Clin Psychobiol, E-08036 Barcelona, Spain

来源：

NEURORADIOLOGY | 2012年 / 54卷 / 05期

基金：

英国医学研究理事会;

关键词：

Diffusion tensor imaging; Neonate; Perinatal brain injury; Magnetic resonance imaging; NEONATAL CEREBRAL INFARCTION; ARTERIAL ISCHEMIC-STROKE; WHITE-MATTER; WALLERIAN DEGENERATION; DIFFUSION; NEWBORN; PREDICTION; ANISOTROPY; CHILDREN;

D O I：

10.1007/s00234-011-0969-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Our aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function. We studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination. Conventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry. Conventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.

引用

页码：507 / 516

页数：10

共 28 条

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