Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers

被引：144

作者：

Cheng, YY ^{[1
]}

Xu, TW

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Lab Funct Membrane, Anhua 230026, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 40卷 / 11期

关键词：

polyamidoamine dendrimers; guest molecules; drug carrier; solubility; NSAIDs;

D O I：

10.1016/j.ejmech.2005.06.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen, Ibuprofen, Diflunisal and Naproxen were measured in the presence of the ethylenediamme (EDA) core polyamidoamine (PAMAM) dendrimers at 37 degrees C. The effect of concentration and generation of the PAMAM dendrimers has been investigated. Results showed that the solubility of NSAIDs in the PAMAM dendrimer solutions was approximately proportional to dendrimer concentration; the solubility of NSAIDs in higher generation PAMAM solutions was in fact higher that those in lower ones; the order of increased solubility of NSAIDs in PAMAM dendrimers at a constant dendrimer concentration and generation was Naproxen > Ketoprofen > Ibuprofen > Diflunisal. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of NSAIDs. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：1188 / 1192

页数：5

共 24 条

[1] Synthesis and antitumour activity of new dendritic polyamines-(imide-DNA-intercalator) conjugates:: potent Lck inhibitors [J].

Braña, MF ;

Domínguez, G ;

Sáez, B ;

Romerdahl, C ;

Robinson, S ;

Barlozzari, T .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (07) :541-551

[2]

Chie K., 2000, BIOCONJUGATE CHEM, V17, P910

[3]

DENIS MM, 1999, AM J MED, V107, pS37

[4] Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications [J].

Esfand, R ;

Tomalia, DA .

DRUG DISCOVERY TODAY, 2001, 6 (08) :427-436

[5] Controlling solubility and modulating peripheral function in dendrimer encapsulated dyes [J].

Furuta, P ;

Fréchet, JMJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (43) :13173-13181

[6] RISK FOR SERIOUS GASTROINTESTINAL COMPLICATIONS RELATED TO USE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS - A METAANALYSIS [J].

GABRIEL, SE ;

JAAKKIMAINEN, L ;

BOMBARDIER, C .

ANNALS OF INTERNAL MEDICINE, 1991, 115 (10) :787-796

[7] Anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs [J].

Gibson, D ;

Binyamin, I ;

Haj, M ;

Ringel, I ;

Ramu, A ;

Katzhendler, J .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1997, 32 (10) :823-831

[8]

GUTTHANN SP, 1994, PHARMACOEPIDEM DR S, V3, pS63

[9] Binding of ketoprofen enantiomers in various human albumin preparations [J].

Lagrange, F ;

Péhourcq, F ;

Matoga, M ;

Bannwarth, B .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 23 (05) :793-802

[10]

Makiko F, 2000, INT J PHARMACEUT, V205, P117

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