学术探索
学术期刊
新闻热点
数据分析
智能评审

Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications

被引：1334
作者：
Esfand, R
Tomalia, DA
机构：
[1] Univ Michigan, Ctr Biol Nanotechnol, Ann Arbor, MI 48109 USA
[2] Dendrit Sci, Ann Arbor, MI 48104 USA
来源：
DRUG DISCOVERY TODAY | 2001年 / 6卷 / 08期
关键词：
D O I：
10.1016/S1359-6446(01)01757-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poly(amidoamine) (PAMAM) dendrimers are the first complete dendrimer family to be synthesized, characterized and commercialized. Based on this extensive activity, they are recognized as a unique new class of synthetic nanostructures. Dendrimers allow the precise control of size, shape and placement of functional groups that is desirable for many life science applications. From this perspective, this review focuses on crucial properties of biomimetic dendrimers that will broaden the potential for their use as macromolecular vectors in novel drug delivery and biomedical applications.
引用
收藏
页码：427 / 436
页数：10
相关论文
共 76 条
  • [1] AHARONI SM, 1983, POLYM COMMUN, V24, P132
  • [2] SIZE AND SOLUTION PROPERTIES OF GLOBULAR TERT-BUTYLOXYCARBONYL-POLY(ALPHA,XI-L-LYSINE)
    AHARONI, SM
    CROSBY, CR
    WALSH, EK
    [J]. MACROMOLECULES, 1982, 15 (04) : 1093 - 1098
  • [3] [Anonymous], POLYMERS ORIGIN GROW
  • [4] [Anonymous], ENCY PHARM TECHNOLOG
  • [5] Balogh L, 2000, CHEM INNOV, V30, P19
  • [6] Dendrimer-silver complexes and nanocomposites as antimicrobial agents
    Balogh, L
    Swanson, DR
    Tomalia, DA
    Hagnauer, GL
    McManus, AT
    [J]. NANO LETTERS, 2001, 1 (01) : 18 - 21
  • [7] About dendrimers: Structure, physical properties, and applications
    Bosman, AW
    Janssen, HM
    Meijer, EW
    [J]. CHEMICAL REVIEWS, 1999, 99 (07) : 1665 - 1688
  • [8] Slab-gel and capillary electrophoretic characterization of polyamidoamine dendrimers
    Brothers, HM
    Piehler, LT
    Tomalia, DA
    [J]. JOURNAL OF CHROMATOGRAPHY A, 1998, 814 (1-2) : 233 - 246
  • [9] Crooks RM, 2001, TOP CURR CHEM, V212, P81
  • [10] Dendrimers with porphyrin cores: Synthetic models for globular heme proteins
    Dandliker, PJ
    Diederich, F
    Zingg, A
    Gisselbrecht, JP
    Gross, M
    Louati, A
    Sanford, E
    [J]. HELVETICA CHIMICA ACTA, 1997, 80 (06) : 1773 - 1801
12345678