Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat

被引:354
作者
Francis, DD [1 ]
Champagne, FC [1 ]
Meaney, MJ [1 ]
机构
[1] McGill Univ, Douglas Hosp, Res Ctr, Dev Neuroendocrinol Lab, Verdun, PQ H4H 1R3, Canada
关键词
maternal behaviour; oxytocin receptors; fear; lactation; rat;
D O I
10.1046/j.1365-2826.2000.00599.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Female Long-Evans rats exhibit stable individual differences in maternal behaviours such as pup licking/grooming and arched-back nursing posture (LG-ABN). These variations in maternal behaviour are accompanied by differences in lactation-induced increases in oxytocin receptor levels in brain regions known to mediate the expression of maternal care in this species (i.e. the bed nucleus of the stria terminalis, the medial preoptic area and the lateral septum). Oxytocin receptor levels in the central nucleus of the amygdala were significantly higher in high compared to low LG-ABN females regardless of reproductive status. These findings suggest that individual differences in maternal behaviour may be directly related to variations in oxytocin receptor expression.
引用
收藏
页码:1145 / 1148
页数:4
相关论文
共 34 条
[21]  
Neumann ID, 2000, NEUROSCIENCE, V95, P567
[22]   Neuroanatomical circuitry for mammalian maternal behavior [J].
Numan, M ;
Sheehan, TP .
INTEGRATIVE NEUROBIOLOGY OF AFFILIATION, 1997, 807 :101-125
[23]   OXYTOCIN-BINDING SITES IN RAT LIMBIC AND HYPOTHALAMIC STRUCTURES - SITE-SPECIFIC MODULATION BY ADRENAL AND GONADAL-STEROIDS [J].
PATCHEV, VK ;
SCHLOSSER, SF ;
HASSAN, AHS ;
ALMEIDA, OFX .
NEUROSCIENCE, 1993, 57 (03) :537-543
[24]  
Paxinos G, 1998, RAT BRAIN IN STEREOTAXIC COORDINATES, FOURTH ED., pix
[25]   INDUCTION OF MATERNAL-BEHAVIOR IN VIRGIN RATS AFTER INTRACEREBROVENTRICULAR ADMINISTRATION OF OXYTOCIN [J].
PEDERSEN, CA ;
PRANGE, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (12) :6661-6665
[26]   OXYTOCIN ANTISERUM DELAYS ONSET OF OVARIAN STEROID-INDUCED MATERNAL-BEHAVIOR [J].
PEDERSEN, CA ;
CALDWELL, JD ;
JOHNSON, MF ;
FORT, SA ;
PRANGE, AJ .
NEUROPEPTIDES, 1985, 6 (02) :175-182
[27]   OXYTOCIN INDUCES MATERNAL-BEHAVIOR IN VIRGIN FEMALE RATS [J].
PEDERSEN, CA ;
ASCHER, JA ;
MONROE, YL ;
PRANGE, AJ .
SCIENCE, 1982, 216 (4546) :648-650
[28]  
PEDERSEN CA, 1995, ANN NY ACAD SCI, V602, P126
[29]   PSYCHOBIOLOGY OF MATERNAL-BEHAVIOR - CONTRIBUTION TO THE CLINICAL UNDERSTANDING OF MATERNAL-BEHAVIOR AMONG HUMANS [J].
ROSENBLATT, JS .
ACTA PAEDIATRICA, 1994, 83 :3-8
[30]  
Stern JM, 1997, DEV PSYCHOBIOL, V31, P19, DOI 10.1002/(SICI)1098-2302(199707)31:1<19::AID-DEV3>3.0.CO