Swelling and Mechanical Properties of Modified HEMA-based Superporous Hydrogels

被引：47

作者：

Omidian, Hossein ^{[1
]}

Park, Kinam ^{[2
,3
]}

Kandalam, Umadevi ^{[4
]}

Rocca, Jose G. ^{[5
]}

机构：

[1] Nova SE Univ, Coll Pharm, Ft Lauderdale, FL 33314 USA

[2] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA

[3] Purdue Univ, Dept Pharmaceut, W Lafayette, IN 47907 USA

[4] Nova SE Univ, Coll Dent Med, Ft Lauderdale, FL 33314 USA

[5] Solara Inc, Miami, FL USA

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2010年 / 25卷 / 05期

关键词：

superporous hydrogel; physical crosslinking; 2-hydroxyethyl methacrylate; ionotropic gelation; toxicity; POLYMER NETWORKS; CROSS-LINKING; DELIVERY; CHITOSAN; BEHAVIOR; BIOCOMPATIBILITY; POLYACRYLAMIDE;

D O I：

10.1177/0883911510375175

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Superporous hydrogels (SPHs), based on poly(2-hydroxyethyl methacrylate) (PHEMA), were prepared by adding minute amounts of an ioncomplexable hydrophilic acrylic acid. PHEMA SPHs are generally strong, but their swelling is minimal. To improve the swelling, different poly(HEMA-co-acrylic acid) hydrogels were polymerized and crosslinked, then physically treated with divalent calcium and trivalent aluminum cations. The incorporation of acrylic acid copolymer into the SPH, followed by crosslinking of the copolymer with calcium or aluminum ions produced SPHs with improved swelling and strength. Cells in the presence of hydrogel showed high viability indicating the absence of cytotoxicity and stimulatory effect.

引用

页码：483 / 497

页数：15

共 40 条

[1] Equilibrium swelling behavior and elastic properties of polymer-clay nanocomposite hydrogels [J].

Abdurrahmanoglu, Suzan ;

Can, Volkan ;

Okay, Oguz .

JOURNAL OF APPLIED POLYMER SCIENCE, 2008, 109 (06) :3714-3724

[2] Optimization of urease immobilization onto non-porous HEMA incorporated poly(EGDMA) microbeads and estimation of kinetic parameters [J].

Ayhan, F ;

Ayhan, H ;

Piskin, E ;

Tanyolaç, A .

BIORESOURCE TECHNOLOGY, 2002, 81 (02) :131-140

[3] EFFECT OF INITIAL TOTAL MONOMER CONCENTRATION ON THE SWELLING BEHAVIOR OF CATIONIC ACRYLAMIDE-BASED HYDROGELS [J].

BAKER, JP ;

HONG, LH ;

BLANCH, HW ;

PRAUSNITZ, JM .

MACROMOLECULES, 1994, 27 (06) :1446-1454

[4] Lipase immobilized on poly(VP-co-HEMA) hydrogel for esterification reaction [J].

Basri, M ;

Samsudin, S ;

Bin Ahmad, M ;

Razak, CNA ;

Salleh, AB .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1999, 81 (03) :205-217

[5] STUDY ON PVA HYDROGEL CROSS-LINKED BY EPICHLOROHYDRIN [J].

BO, J .

JOURNAL OF APPLIED POLYMER SCIENCE, 1992, 46 (05) :783-786

[6] Characterization of hydrogel blends of poly(vinyl pyrrolidone) and poly(vinyl alcohol vinyl acetate) [J].

CauichRodriguez, JV ;

Deb, S ;

Smith, R .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1996, 7 (05) :269-272

[7] Gastric retention properties of superporous hydrogel composites [J].

Chen, J ;

Blevins, WE ;

Park, H ;

Park, K .

JOURNAL OF CONTROLLED RELEASE, 2000, 64 (1-3) :39-51

[8]

Chen J, 1999, J MACROMOL SCI PURE, VA36, P917

[9] Surface grafting polymerization and crosslinking of thermosensitive NIPAAm hydrogels onto plasma pretreated substrates and drug delivery properties [J].

Chen, KS ;

Chou, CW ;

Hsu, SH ;

Lin, HR .

THERMEC'2003, PTS 1-5, 2003, 426-4 :3267-3271

[10] Preparation and characterization of hydroxyapatide powder/poly(Acrylamide/Itaconic acid) composite hydrogel [J].

Chen, KS ;

Yang, MR ;

Ku, YA ;

Chen, TM ;

Lin, FH .

THERMEC'2003, PTS 1-5, 2003, 426-4 :2101-2106

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