Paramutation's Properties and Puzzles

被引：53

作者：

Chandler, Vicki L. ^{[1
]}

机构：

[1] Univ Arizona, Dept Plant Sci, Inst BIO5, Tucson, AZ 85719 USA

来源：

SCIENCE | 2010年 / 330卷 / 6004期

基金：

美国国家科学基金会;

关键词：

MAIZE; TRANS; INHERITANCE; EXPRESSION; LOCUS;

D O I：

10.1126/science.1191044

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Paramutation refers to the process by which homologous DNA sequences communicate in trans to establish meiotically heritable expression states. Although mechanisms are unknown, current data are consistent with the hypothesis that the establishment and heritable transmission of specific chromatin states underlies paramutation. Transcribed, noncoding tandem repeats and proteins implicated in RNA-directed transcriptional silencing in plants and yeast are required for paramutation, yet the specific molecules mediating heritable silencing remain to be determined.

引用

页码：628 / 629

页数：2

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