Paramutation in maize: RNA mediated trans-generational gene silencing

被引：104

作者：

Arteaga-Vazquez, Mario Alberto ^{[1
]}

Chandler, Vicki Lynn ^{[1
]}

机构：

[1] Univ Arizona, Inst BIO5, Tucson, AZ 85721 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

R-STIPPLED MAIZE; POLYMERASE-IV; DNA METHYLATION; EPIGENETIC INHERITANCE; ZEA-MAYS; P1; GENE; B-LOCUS; ARABIDOPSIS; HETEROCHROMATIN; ORGANIZATION;

D O I：

10.1016/j.gde.2010.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Paramutation involves trans-interactions between alleles or homologous sequences that establish distinct gene expression states that are heritable for generations. It was first described in maize by Alexander Brink in the 1950s, with his studies of the red1 (r1) locus. Since that time, paramutation-like phenomena have been reported in other maize genes, other plants, fungi, and animals. Paramutation can occur between endogenous genes, two transgenes or an endogenous gene, and transgene. Recent results indicate that paramutation involves RNA-mediated heritable chromatin changes and a number of genes implicated in RNAi pathways. However, not all aspects of paramutation can be explained by known mechanisms of RNAi-mediated transcriptional silencing.

引用

页码：156 / 163

页数：8

共 61 条

[1]

An RNA-dependent RNA polymerase is required for paramutation in maize [J].

Alleman, Mary ;

Sidorenko, Lyudmila ;

McGinnis, Karen ;

Seshadri, Vishwas ;

Dorweiler, Jane E. ;

White, Joshua ;

Sikkink, Kristin ;

Chandler, Vicki L. .

NATURE, 2006, 442 (7100) :295-298

[2]

SELF-ASSOCIATION OF THE DROSOPHILA-ZESTE PROTEIN IS RESPONSIBLE FOR TRANSVECTION EFFECTS [J].

BICKEL, S ;

PIRROTTA, V .

EMBO JOURNAL, 1990, 9 (09) :2959-2967

[3]

BRINK RA, 1956, GENETICS, V41, P872

[4]

Two-step recruitment of RNA-directed DNA methylation to tandem repeats [J].

Chan, Simon W. -L. ;

Zhang, Xiaoyu ;

Bernatavichute, Yana V. ;

Jacobsen, Steven E. .

PLOS BIOLOGY, 2006, 4 (11) :1923-1933

[5]

Paramutation: From maize to mice [J].

Chandler, Vicki L. .

CELL, 2007, 128 (04) :641-645

[6]

Chromatin conversations: Mechanisms and implications of paramutation [J].

Chandler, VL ;

Stam, M .

NATURE REVIEWS GENETICS, 2004, 5 (07) :532-544

[7]

Chandler VL, 2002, ADV GENET, V46, P215

[8]

2 REGULATORY GENES OF THE MAIZE ANTHOCYANIN PATHWAY ARE HOMOLOGOUS - ISOLATION OF B UTILIZING R GENOMIC SEQUENCES [J].

CHANDLER, VL ;

RADICELLA, JP ;

ROBBINS, TP ;

CHEN, JC ;

TURKS, D .

PLANT CELL, 1989, 1 (12) :1175-1183

[9]

Paramutation in maize [J].

Chandler, VL ;

Eggleston, WB ;

Dorweiler, JE .

PLANT MOLECULAR BIOLOGY, 2000, 43 (2-3) :121-145

[10]

A maize Myb homolog is encoded by a multicopy gene complex [J].

Chopra, S ;

Athma, P ;

Li, XG ;

Peterson, T .

MOLECULAR AND GENERAL GENETICS, 1998, 260 (04) :372-380

← 1 2 3 4 5 6 7 →