Aβ(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau

被引：33

作者：

Ghribi, O

Prammonjago, P

Herman, MM

Spaulding, NK

Savory, J

机构：

[1] Univ Virginia, Hlth Sci Ctr, Dept Pathol, Charlottesville, VA 22908 USA

[2] NIMH, IRP, NIH, Bethesda, MD USA

[3] Univ Virginia, Hlth Sci Ctr, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

来源：

MOLECULAR BRAIN RESEARCH | 2003年 / 119卷 / 02期

关键词：

A beta; lithium; tau; JNK; EPK; caspase-3;

D O I：

10.1016/j.molbrainres.2003.09.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Administration of Abeta(1-42) into the rabbit brain induces apoptosis and phosphorylation of tau. These Abeta effects correlate with the activation of JNK and ERK, but not of p38. Treatment with 7 mM lithium inhibits apoptosis, modulates JNK and ERK and does not affect the phosphorylation of tau. Our results demonstrate that lithium, at this dose, effectively inhibits the Abeta-induced apoptosis but has no effect on tau phosphorylation, and that MAP kinases are not involved in the phosphorylation of tau. (C) 2003 Elsevier B.V. All rights reserved.

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收藏

页码：201 / 206

页数：6

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