Genetic Variations in Tumor Necrosis Factor Alpha, Interleukin-10 Genes, and Migraine Susceptibility

被引：27

作者：

Ates, Omer ^{[1
]}

Kurt, Semiha ^{[2
]}

Altinisik, Julide ^{[3
]}

Karaer, Hatice ^{[2
]}

Sezer, Saime ^{[1
]}

机构：

[1] Gaziosmanpasa Univ, Fac Med, Dept Med Biol, TR-60100 Tokat, Turkey

[2] Gaziosmanpasa Univ, Fac Med, Dept Neurol, TR-60100 Tokat, Turkey

[3] Balikesir Univ, Fac Med, Dept Med Biol, Balikesir, Turkey

来源：

PAIN MEDICINE | 2011年 / 12卷 / 10期

关键词：

Migraine; TNF-alpha; IL-10; Genetic Susceptibility; Polymorphism; TNF-ALPHA; CYTOKINE LEVELS; IMMUNE-SYSTEM; POLYMORPHISM; PROMOTER; ASSOCIATION; IL-10;

D O I：

10.1111/j.1526-4637.2011.01200.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Objectives. Migraine is a very common headache disorder and pathogenesis of the disease is still largely unknown. Cytokine genes have been implicated in migraine susceptibility. The present study was designed to explore the associations of polymorphisms in the tumor necrosis factor alpha (TNF-alpha), interleukin-10 (IL-10) gene, and IL-10 haplotypes in Turkish migraine patients. Methods. TNF-alpha-308G/A, IL-10-1082G/ A, -819C/T, and -592C/A polymorphisms in 203 migraine patients and 202 healthy subjects were analyzed by using amplification refractory mutation system-polymerase chain reaction. Results. The -308G/A genotypic and -308A allelic frequency of TNF-alpha polymorphism was higher in migraine patients than healthy controls, and significant association was found between migraine and TNF-alpha -308G/A polymorphism (Bonferroni correction [Pc]: <0.0001, odds ratio: 2.16, 95% confidence interval: 1.44-3.28). No statistically significant association was found between IL-10 -1082G/A, -819C/T, and -592C/A polymorphisms and haplotypes containing these alleles and migraine. Conclusions. This study reflect that TNF-alpha-308G/A polymorphism may be one of the many genetic factors for migraine susceptibility in the Turkish population.

引用

页码：1464 / 1469

页数：6

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