INTERFERENCE AMONG VIRUSES CIRCULATING AND ADMINISTERED IN HUNGARY FROM 1931 TO 2008

被引：5

作者：

Berencsi, Gy. ^{[1
]}

Kapusinszky, Beatrix ^{[1
]}

Rigo, Zita ^{[1
]}

Szomor, Katalin ^{[1
]}

机构：

[1] Natl Ctr Epidemiol, Div Virol, H-1097 Budapest, Hungary

来源：

ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA | 2010年 / 57卷 / 02期

关键词：

epidemic interference; oral polio vaccine; influenza epidemics; EPIDEMIC VIRUSES; INFLUENZA-VIRUS; 11' PRIME; DISEASE; POLIOMYELITIS; INFECTION; VACCINE; RECURRENCE; SIMULATION; OUTBREAKS;

D O I：

10.1556/AMicr.57.2010.2.1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral interference was discovered about 60 years ago. Molecular epidemiology revealed that this phenomenon possesses important biological implications, it can reduce the epidemic spread of certain viruses from time to time (influenza and enteroviruses) and the efficiency of live vaccination can be impaired, too. Phenomena observed during the last 80 years in Hungary are analyzed. It is suggested to concentrate the distribution of MMR vaccines to seasons of limited influenza and enterovirus circulation. Interference seems to impair the progress of wild poliovirus eradication in the endemic tropical countries. It is recommended to enhance enterovirus surveillance in the region of European countries, since the exchange of the oral poliovirus vaccine to the enhanced inactivated polio vaccine might result in enhanced circulation of non-polio enteroviruses leading to the increase in the number of type I (juvenile) diabetes patients.

引用

页码：73 / 86

页数：14

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