Neurotrophins as synaptic modulators

被引:1480
作者
Poo, MM [1 ]
机构
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
关键词
D O I
10.1038/35049004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The role of neurotrophins as regulatory factors that mediate the differentiation and survival of neurons has been well described. More recent evidence indicates that neurotrophins may also act as synaptic modulators. Here, I review the evidence that synaptic activity regulates the synthesis, secretion and action of neurotrophins, which can in turn induce immediate changes in synaptic efficacy and morphology. By this account, neurotrophins may participate in activity dependent synaptic plasticity linking synaptic activity with long-term functional and structural modification of synaptic connections.
引用
收藏
页码:24 / 32
页数:9
相关论文
共 124 条
[21]   EFFECTS OF BRAIN-DERIVED NEUROTROPHIC FACTOR ON OPTIC AXON BRANCHING AND REMODELING IN-VIVO [J].
COHENCORY, S ;
FRASER, SE .
NATURE, 1995, 378 (6553) :192-196
[22]  
Conner JM, 1997, J NEUROSCI, V17, P2295
[23]   EVOKED NEURONAL SECRETION OF FALSE TRANSMITTERS [J].
DAN, Y ;
SONG, HJ ;
POO, MM .
NEURON, 1994, 13 (04) :909-917
[24]   THE NEUROTROPHINS BDNF, NT-3, AND NGF DISPLAY DISTINCT PATTERNS OF RETROGRADE AXONAL-TRANSPORT IN PERIPHERAL AND CENTRAL NEURONS [J].
DISTEFANO, PS ;
FRIEDMAN, B ;
RADZIEJEWSKI, C ;
ALEXANDER, C ;
BOLAND, P ;
SCHICK, CM ;
LINDSAY, RM ;
WIEGAND, SJ .
NEURON, 1992, 8 (05) :983-993
[25]   Activity- and Ca2+-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons [J].
Du, J ;
Feng, LY ;
Yang, F ;
Lu, B .
JOURNAL OF CELL BIOLOGY, 2000, 150 (06) :1423-1433
[26]   Dendritic spine changes associated with hippocampal long-term synaptic plasticity [J].
Engert, F ;
Bonhoeffer, T .
NATURE, 1999, 399 (6731) :66-70
[27]   INCREASED LEVELS OF MESSENGER-RNAS FOR NEUROTROPHIC FACTORS IN THE BRAIN DURING KINDLING EPILEPTOGENESIS [J].
ERNFORS, P ;
BENGZON, J ;
KOKAIA, Z ;
PERSSON, H ;
LINVALL, O .
NEURON, 1991, 7 (01) :165-176
[28]  
Fawcett JP, 1997, J BIOL CHEM, V272, P8837
[29]   Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus [J].
Figurov, A ;
PozzoMiller, LD ;
Olafsson, P ;
Wang, T ;
Lu, B .
NATURE, 1996, 381 (6584) :706-709
[30]   ARIA: A neuromuscular junction neuregulin [J].
Fischbach, GD ;
Rosen, KM .
ANNUAL REVIEW OF NEUROSCIENCE, 1997, 20 :429-458