Erythropoietin as an angiogenic factor

被引：144

作者：

Ribatti, D

Vacca, A

Roccaro, AM

Crivellato, E

Presta, M

机构：

[1] Univ Bari, Sch Med, Dept Human Anat & Histol, Bari, Italy

[2] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Bari, Italy

[3] Univ Udine, Sch Med, Dept Med & Morphol Res, Sect Anat, I-33100 Udine, Italy

[4] Univ Brescia, Sch Med, Dept Biomed Sci & Biotechnol, Unit Gen Pathol & Immunol, Brescia, Italy

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 33卷 / 10期

关键词：

angiogenesis; central nervous system; erythropoietin; hypoxia; tumour;

D O I：

10.1046/j.1365-2362.2003.01245.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Erythropoietin (Epo) is produced by the fetal liver and adult kidney and is an essential stimulator of erythropoiesis. It has, however, been shown to modulate host cellular signal transduction pathway to perform many other functions. New sites of Epo production have been found, such as the female reproductive organs and central nervous system. This review summarizes the involvement of Epo in the regulation of angiogenesis in both normal and pathological conditions.

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收藏

页码：891 / 896

页数：6

相关论文

共 74 条

[1] Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma [J].

Acs, G ;

Zhang, PJ ;

Rebbeck, TR ;

Acs, P ;

Verma, A .

CANCER, 2002, 95 (05) :969-981

[2] Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression [J].

Acs, G ;

Zhang, PJ ;

McGrath, CM ;

Acs, P ;

McBroom, J ;

Mohyeldin, A ;

Liu, SZ ;

Lu, HS ;

Verma, A .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (06) :1789-1806

[3]

Acs G, 2001, CANCER RES, V61, P3561

[4] ERYTHROPOIETIN HAS A MITOGENIC AND POSITIVE CHEMOTACTIC EFFECT ON ENDOTHELIAL-CELLS [J].

ANAGNOSTOU, A ;

LEE, ES ;

KESSIMIAN, N ;

LEVINSON, R ;

STEINER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5978-5982

[5] ERYTHROPOIETIN RECEPTOR MESSENGER-RNA EXPRESSION IN HUMAN ENDOTHELIAL-CELLS [J].

ANAGNOSTOU, A ;

LIU, ZY ;

STEINER, M ;

CHIN, K ;

LEE, ES ;

KESSIMIAN, N ;

NOGUCHI, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3974-3978

[6] Erythropoietin stimulates vasculogenesis in neonatal rat mesenteric microvascular endothelial cells [J].

Ashley, RA ;

Dubuque, SH ;

Dvorak, B ;

Woodward, SS ;

Williams, SK ;

Kling, PJ .

PEDIATRIC RESEARCH, 2002, 51 (04) :472-478

[7] Expression of the erythropoietin receptor by trophoblast cells in the human placenta [J].

Benyo, DF ;

Conrad, KP .

BIOLOGY OF REPRODUCTION, 1999, 60 (04) :861-870

[8] A potential role for erythropoietin in focal permanent cerebral ischemia in mice [J].

Bernaudin, M ;

Marti, HH ;

Roussel, S ;

Divoux, D ;

Nouvelot, A ;

MacKenzie, E ;

Petit, E .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (06) :643-651

[9]

BIKFALVI A, 1994, LEUKEMIA, V8, P523

[10] Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo [J].

Bjornson, CRR ;

Rietze, RL ;

Reynolds, BA ;

Magli, MC ;

Vescovi, AL .

SCIENCE, 1999, 283 (5401) :534-537

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