Erythropoietin as an angiogenic factor

被引：144

作者：

Ribatti, D

Vacca, A

Roccaro, AM

Crivellato, E

Presta, M

机构：

[1] Univ Bari, Sch Med, Dept Human Anat & Histol, Bari, Italy

[2] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Bari, Italy

[3] Univ Udine, Sch Med, Dept Med & Morphol Res, Sect Anat, I-33100 Udine, Italy

[4] Univ Brescia, Sch Med, Dept Biomed Sci & Biotechnol, Unit Gen Pathol & Immunol, Brescia, Italy

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 33卷 / 10期

关键词：

angiogenesis; central nervous system; erythropoietin; hypoxia; tumour;

D O I：

10.1046/j.1365-2362.2003.01245.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Erythropoietin (Epo) is produced by the fetal liver and adult kidney and is an essential stimulator of erythropoiesis. It has, however, been shown to modulate host cellular signal transduction pathway to perform many other functions. New sites of Epo production have been found, such as the female reproductive organs and central nervous system. This review summarizes the involvement of Epo in the regulation of angiogenesis in both normal and pathological conditions.

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收藏

页码：891 / 896

页数：6

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