Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

被引：34

作者：

Kan, T ^{[1
]}

Tominari, Y ^{[1
]}

Morohashi, Y ^{[1
]}

Natsugari, H ^{[1
]}

Tomita, T ^{[1
]}

Iwatsubo, T ^{[1
]}

Fukuyama, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 17期

关键词：

D O I：

10.1039/b306970b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A benzophenone cross-linking group and a biotin-tag hybrid, resin 1a, attached to our novel resin 2 was readily converted to the photoaffnity probe 20 by condensation with the ligand carboxylic acid 19 and cleavage from the resin without purification.

引用

页码：2244 / 2245

页数：2

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