Insight into renal Mg2+ transporters

被引：28

作者：

Ferre, Silvia ^{[1
]}

Hoenderop, Joost G. J. ^{[1
]}

Bindels, Rene J. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, NL-6500 HB Nijmegen, Netherlands

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2011年 / 20卷 / 02期

关键词：

distal convoluted tubule; Mg2+ extrusion; novel Mg2+ transporters; CONE-ROD DYSTROPHY; FUNCTIONAL-CHARACTERIZATION; MAGNESIUM; MUTATIONS; TRPM6; GENE; ANCIENT; PROTEIN; HYPOMAGNESEMIA; IDENTIFICATION;

D O I：

10.1097/MNH.0b013e3283435ee4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review This review aims to describe the recent findings concerning novel Mg2+ transporters as putative interesting players in renal transepithelial Mg2+ transport. Recent findings So far, the best characterized Mg2+ transport proteins are found in prokaryotes and yeast cells. In recent years, phylogenetic analysis and differential gene expression studies have led to the identification of numerous genes associated with Mg2+ transport in eukaryotes. In addition to the well known transient receptor potential channel melastatin (TRPM), members 6 and 7, and the mitochondrial transporter Mrs2, additional Mg2+-transporting protein families can be acknowledged including the magnesium (Mag) transporters, the solute carrier (SLC) family 41 members, ancient conserved domain proteins (ACDP), nonimprinted in Prader-Willi/Angelman syndrome (NIPA) proteins, membrane Mg2+ transporters (MMgT) and huntingtin-interacting protein 14 (HIP14). Summary The identification of several mammalian proteins involved in Mg2+ transport highlights the physiological importance of this cation and its tight regulation in numerous tissues. Further investigation of these transporters might represent a key tool to complement our current knowledge about renal Mg2+ handling.

引用

页码：169 / 176

页数：8

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