Highly efficient phosphate diester hydrolysis and DNA interaction by a new unsymmetrical FeIIINiII model complex

被引：69

作者：

Batista, SC

Neves, A

Bortoluzzi, AJ

Vencato, I

Peralta, RA

Szpoganicz, B

Aires, VVE

Terenzi, H

Severino, PC

机构：

[1] Univ Fed Santa Catarina, LABINC, Lab Bioinorgan & Cristal, Dept Quim, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Bioquim, Lab Expressao Genica, BR-88040900 Florianopolis, SC, Brazil

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2003年 / 6卷 / 08期

关键词：

crystal structure; dinuclear (FeNiII)-Ni-III complex; unsymmetric ligand; phosphatase-like activity; DNA interaction; cyclic voltammetry;

D O I：

10.1016/S1387-7003(03)00219-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new heterodinuclear mixed valence complex [(FeNiII)-Ni-III(BPBPMP)(OAc)(2)]ClO4 1 with the unsymmetrical N5O2 donor ligand 2-bis[{(2-pyridylmethyl)-aminomethyl}-6-{(2-hydroxybenzyl)(2-pyridylmethyl)}-aminomethyl]-4-methylphenol (H2BPBPMP) has been synthesized and characterized. 1 crystallizes in the monoclinic system, space group P2(1)/n, a = 12.497(2), b = 18.194(4), c = 16.929(3) Angstrom, beta = 94.11(3)degrees, V = 3839.3(12) Angstrom(3) and has an Fe-III Ni-II(mu-phenoxo)-bis(mu-carboxylato) core. Solution studies of 1 indicate that a pH-induced change in the bridging acetate occurs and the formation of an active [(OH)Fe-III(mu-OH)Ni-II(OH2)](+) species as the catalyst for phosphate diester hydrolysis and DNA interaction is proposed. In addition, the results presented here suggest that Ni-II would be a good candidate as a substitute of W in purple acid phosphatases. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：1161 / 1165

页数：5

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