Seronegative spondyloarthropathies and HLA-B27 subtypes: A study in Asian Indians.

被引：38

作者：

Kanga, U ^{[1
]}

Mehra, NK ^{[1
]}

Larrea, CL ^{[1
]}

Lardy, NM ^{[1
]}

Kumar, A ^{[1
]}

Feltkamp, TEW ^{[1
]}

机构：

[1] ALL INDIA INST MED SCI,DEPT HISTOCOMPATIBIL & IMMUNOGENET,NEW DELHI 29,INDIA

来源：

CLINICAL RHEUMATOLOGY | 1996年 / 15卷

关键词：

HLA-B27; subtypes; ankylosing spondylitis; seronegative; spondyloarthropathies;

D O I：

10.1007/BF03342638

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, 60 HLA-B27 + ve SSA patients and 17 healthy controls belonging to North India were analyzed to ascertain heterogeneity of the B27 molecule in this population. ID-IEF and PCR-SSOP technologies were used to analyze polymorphism in exon 2 and 3 of the HLA-B27 gene. Four different subtypes were encountered: B*2702,04,05 and 07. Other subtypes of B27 viz B*2701, 03, 06 and 08 were not encountered. B*2704 (common oriental subtype) and B*2705 (common Caucasian subtype) were the most common subtypes in the control and patient groups. B*2704 was less frequently encountered in both groups and B*2702 was found in only one AAU patient. B*2704 was the predominant subtype in the AS group (70.8%) compared to its frequency of 47% in healthy controls (RR=2.73) while in the undiff SpA group, B*2705 occurred most frequently (73.1%, RR=3.05). B27 subtypes segregated differently in males and females. 12 of the 17 male AS patients carried B*2704 as compared to 1 of 8 healthy males (X(2)=3.9, P < 0.05), On the other hand, in the undiff SpA, B*2705 was significantly raised in female patients (100%) as compared to healthy females (22.2%, X(2)=4.9, P < 0.05). Subtype distribution is indicative of racial admixture in the Asian Indian population.

引用

页码：13 / 18

页数：6

共 24 条

[11]

DERHAAG PJFM, 1988, INVEST OPHTH VIS SCI, V29, P1137

[12] THE EUROPEAN-SPONDYLARTHROPATHY-STUDY-GROUP PRELIMINARY CRITERIA FOR THE CLASSIFICATION OF SPONDYLARTHROPATHY [J].

DOUGADOS, M ;

VANDERLINDEN, S ;

JUHLIN, R ;

HUITFELDT, B ;

AMOR, B ;

CALIN, A ;

CATS, A ;

DIJKMANS, B ;

OLIVIERI, I ;

PASERO, G ;

VEYS, E ;

ZEIDLER, H .

ARTHRITIS AND RHEUMATISM, 1991, 34 (10) :1218-1227

[13] MOLECULAR ANALYSIS OF HLA-B27 HAPLOTYPES IN CAUCASOIDS - FREQUENCIES OF B27-CW IN JEWISH AND SPANISH POPULATIONS [J].

GONZALEZROCES, S ;

BRAUTBAR, C ;

PENA, M ;

DOMINGUEZ, O ;

COTO, E ;

ALVAREZ, V ;

SEGAL, R ;

LOPEZLARREA, C .

HUMAN IMMUNOLOGY, 1994, 41 (02) :127-134

[14] HLA CLASS-I TYPING BY PCR - HLA-B27 AND AN AFRICAN B27 SUBTYPE [J].

HILL, AVS ;

ALLSOPP, CEM ;

KWIATKOWSKI, D ;

ANSTEY, NM ;

GREENWOOD, BM ;

MCMICHAEL, AJ .

LANCET, 1991, 337 (8742) :640-642

[15]

Khan Muhammad Asim, 1995, Current Opinion in Rheumatology, V7, P263, DOI 10.1097/00002281-199507000-00001

[16]

KRYLOV MIU, 1994, MOL GEN MIKROBIOL VI, V5, P27

[17]

LARREA CLL, 1995, TISSUE ANTIGENS, V45, P169

[18]

LOPEZ D, 1994, J IMMUNOL, V152, P5557

[19]

MACLEAN IL, 1993, CLIN EXP IMMUNOL, V91, P214

[20] HLA-B27 SUBTYPES - IMPLICATIONS FOR THE SPONDYLOARTHROPATHIES [J].

MACLEAN, L .

ANNALS OF THE RHEUMATIC DISEASES, 1992, 51 (08) :929-931

← 1 2 3 →