Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy

被引：127

作者：

Jang, WD

Nishiyama, N

Zhang, GD

Harada, A

Jiang, DL

Kawauchi, S

Morimoto, Y

Kikuchi, M

Koyama, H

Aida, T

Kataoka, K

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan

[2] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, Bunkyo Ku, Tokyo 1138656, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Clin Vasc Regenerat, Bunkyo Ku, Tokyo 1138655, Japan

[4] Natl Def Med Coll, Dept Med Engn, Tokorozawa, Saitama 3598513, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 03期

关键词：

block copolymers; dendrimers; drug delivery; micelles; porphyrinoids;

D O I：

10.1002/anie.200461603

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photo finish: A polymeric micelle system is formed in aqueous media by electrostatic assembly of an anionic dendrimeric porphyrin and a poly(ethylene glycol)poly(L-lysine) block copolymer (see picture). The micelles exhibit high photocytotoxicity and stability. The hydrodynamic size (ca. 60 nim) makes this polymeric micelle system suitable for intravenous administration in photodynamic tumor therapy. (Figure Presented).

引用

页码：419 / 423

页数：5