Optical imaging of metastatic tumors using a folate-targeted fluorescent probe

被引：67

作者：

Kennedy, MD ^{[1
]}

Jallad, KN ^{[1
]}

Thompson, DH ^{[1
]}

Ben-Amotz, D ^{[1
]}

Low, PS ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2003年 / 8卷 / 04期

关键词：

folate receptor; optical imaging of tumors; tumor targeting; folate-fluorescent probe conjugates;

D O I：

10.1117/1.1609453

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the use of a tumor targeting ligand, the vitamin folic acid, to deliver an attached fluorescent probe to both primary and metastatic tumors overexpressing the folate receptor. Upon laser excitation, derived images of normal tissues generally show little or no fluorescence, whereas images of folate receptor-expressing tumors display bright fluorescence that can be easily distinguished from adjacent normal tissue. Furthermore, metastatic tumor loci of submillimeter size can also be visualized without the aid of image processing or enhancement. The sharp distinction between tumor and normal tissues provided by this technique could find application in the localization and resection of tumor tissue during surgery or in the enhanced endoscopic detection and staging of cancers. (C) 2003 Society of Photo-Optical Instrumentation Engineers.

引用

页码：636 / 641

页数：6

共 54 条

[1] Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging [J].