Synthesis of photolabile 2-(2-nitrophenyl)propyloxycarbonyl protected amino acids

被引：31

作者：

Bhushan, KR ^{[1
]}

DeLisi, C ^{[1
]}

Laursen, RA ^{[1
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 47期

关键词：

peptide synthesis; photolabile protecting group; photolithography; microarray;

D O I：

10.1016/j.tetlet.2003.09.155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 2-(2-nitrophenyl)propyloxycarbonyl (NPPOC) group has been introduced as a photolabile amino protecting group for amino acids to be used as building blocks in photolithographic solid-phase peptide synthesis. NPPOC-protected amino acids were found to be cleaved in the presence of UV light about twice as fast as the corresponding o-nitroveratryloxycarbonyl (NVOC)-protected amino acids. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：8585 / 8588

页数：4

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