Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes"

被引：221

作者：

Filippi, M

Rovaris, M

Rocca, MA

Sormani, MP

Wolinsky, JS

Comi, G

机构：

[1] Sci Inst Milan, Dept Neurosci, Neuroimaging Res Unit, I-20132 Milan, Italy

[2] Sci Inst Milan, Dept Neurosci, Clin Trials Unit, I-20132 Milan, Italy

[3] Univ Milan, Osped San Raffaele, I-20127 Milan, Italy

[4] Natl Inst Canc Res, Unit Clin Epidemiol & Trials, Genoa, Italy

[5] Univ Texas, Hlth Sci Ctr, Houston, TX USA

来源：

NEUROLOGY | 2001年 / 57卷 / 04期

关键词：

D O I：

10.1212/WNL.57.4.731

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors evaluated whether glatiramer acetate (GA) modifies the severity of tissue damage in 1,722 new lesions from 239 patients with MS enrolled in a placebo-controlled trial monitored with monthly cerebral MRI. The percentage of new lesions that evolved into "black holes" was lower in GA-treated than in placebo patients on scans at 7 (18.9 and 26.3%; p = 0.04) and 8 (15.6 and 31.4%; p = 0.002) months after lesion appearance. GA has a favorable effect on tissue disruption in MS lesions once they are formed.

引用

页码：731 / 733

页数：3