A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo

被引:12
作者
Chimanuka, B
Francois, G
Timperman, G
Vander Heyden, Y
Holenz, J
Plaizier-Vercammen, J
Bringmann, G
机构
[1] Free Univ Brussels, Vakgrp Farmaceut Technol Fys Farm, B-1090 Brussels, Belgium
[2] Inst Trop Med Prince Leopold, B-2000 Antwerp, Belgium
[3] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
关键词
D O I
10.1007/s004360000358
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Chloroquine, artemether and dioncophylline B efficacy against Plasmodium chabaudi was compared. One intraperitoneal injection (10 mg/kg body weight) was given daily over 3 consecutive days to OF1 mice when they were predominantly bearing ring, trophozoite and schizont forms. The parasitaemia was monitored every 2 h during two schizogonic cycles and daily thereafter until parasites were cleared. Chloroquine was more efficient at the trophozoite stage, while artemether was effective against all erythrocytic stages, with a marked efficacy against the trophozoite stage. Chloroquine-treated and artemether-treated parasites displayed a pigment-clumping morphology and lowered the parasitaemia faster than dioncophylline B. Dioncophylline B was effective at trophozoite and schizont stages, but completely ineffective at the ring stage. These results demonstrate that a better timing of drug administration increases the efficacy of common and new antimalarial drugs and provides a model for antimalarial-action monitoring. Drug-induced changes in infected erythrocyte morphology are presented.
引用
收藏
页码:795 / 803
页数:9
相关论文
共 40 条
[21]   MORPHOLOGICAL EFFECTS OF CHLOROQUINE ON PLASMODIUM BERGHEI IN MICE [J].
MACOMBER, PB ;
SPRINZ, H ;
TOUSIMIS, AJ .
NATURE, 1967, 214 (5091) :937-&
[22]   Artemisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy [J].
Meshnick, SR ;
Taylor, TE ;
Kamchonwongpaisan, S .
MICROBIOLOGICAL REVIEWS, 1996, 60 (02) :301-+
[23]   ARTEMISININ (QINGHAOSU) - THE ROLE OF INTRACELLULAR HEMIN IN ITS MECHANISM OF ANTIMALARIAL ACTION [J].
MESHNICK, SR ;
THOMAS, A ;
RANZ, A ;
XU, CM ;
PAN, HZ .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 49 (02) :181-190
[24]   IRON-DEPENDENT FREE-RADICAL GENERATION FROM THE ANTIMALARIAL AGENT ARTEMISININ (QINGHAOSU) [J].
MESHNICK, SR ;
YANG, YZ ;
LIMA, V ;
KUYPERS, F ;
KAMCHONWONGPAISAN, S ;
YUTHAVONG, Y .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (05) :1108-1114
[25]   THE MODE OF ACTION OF ANTIMALARIAL ENDOPEROXIDES [J].
MESHNICK, SR .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 :31-32
[26]   An open randomized trial of artemether versus quinine in the treatment of cerebral malaria in African children [J].
Murphy, S ;
English, M ;
Waruiru, C ;
Mwangi, I ;
Amukoye, E ;
Crawley, J ;
Newton, C ;
Winstanley, P ;
Peshu, N ;
Marsh, K .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1996, 90 (03) :298-301
[28]   Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite [J].
Pandey, AV ;
Tekwani, BL ;
Singh, RL ;
Chauhan, VS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (27) :19383-19388
[29]   PARENTERAL THERAPY OF MODERATELY SEVERE MALARIA - COMPARISON OF INTRAMUSCULAR ARTEMETHER AND INTRAMUSCULAR SULFADOXINE-PYRIMETHAMINE [J].
SALAKO, LA ;
WALKER, O ;
SOWUNMI, A .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 (01) :89-91
[30]   In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs [J].
Skinner, TS ;
Manning, LS ;
Johnston, WA ;
Davis, TME .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1996, 26 (05) :519-525