共 40 条
A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo
被引:12
作者:
Chimanuka, B
Francois, G
Timperman, G
Vander Heyden, Y
Holenz, J
Plaizier-Vercammen, J
Bringmann, G
机构:
[1] Free Univ Brussels, Vakgrp Farmaceut Technol Fys Farm, B-1090 Brussels, Belgium
[2] Inst Trop Med Prince Leopold, B-2000 Antwerp, Belgium
[3] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
关键词:
D O I:
10.1007/s004360000358
中图分类号:
R38 [医学寄生虫学];
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
100103 ;
摘要:
Chloroquine, artemether and dioncophylline B efficacy against Plasmodium chabaudi was compared. One intraperitoneal injection (10 mg/kg body weight) was given daily over 3 consecutive days to OF1 mice when they were predominantly bearing ring, trophozoite and schizont forms. The parasitaemia was monitored every 2 h during two schizogonic cycles and daily thereafter until parasites were cleared. Chloroquine was more efficient at the trophozoite stage, while artemether was effective against all erythrocytic stages, with a marked efficacy against the trophozoite stage. Chloroquine-treated and artemether-treated parasites displayed a pigment-clumping morphology and lowered the parasitaemia faster than dioncophylline B. Dioncophylline B was effective at trophozoite and schizont stages, but completely ineffective at the ring stage. These results demonstrate that a better timing of drug administration increases the efficacy of common and new antimalarial drugs and provides a model for antimalarial-action monitoring. Drug-induced changes in infected erythrocyte morphology are presented.
引用
收藏
页码:795 / 803
页数:9
相关论文