Control of cell cycle arrest by the Mec1(sc)/Rad3(sp) DNA structure checkpoint pathway

被引：73

作者：

Carr, AM

机构：

[1] MRC Cell Mutation Unit, Sussex University, BN1 9RR, Falmer

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(97)80115-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Mec1(sc)/Rad3(sp) protein family is central to the checkpoint pathways of cells. Functions upstream and downstream of Mec1(sc)/Rad3(sp) show both similarities and differences when compared between organisms. Analogy with a related protein, DNAPK(cs), suggests that different subunits may activate Mec1(sc)/Rad3(sp) in response to specific DNA or DNA-protein structures.

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页码：93 / 98

页数：6

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