Cardiac regeneration by progenitor cells - bedside before bench?

被引：3

作者：

Bauersachs, J ^{[1
]}

Thum, T ^{[1
]}

Frantz, S ^{[1
]}

Ertl, G ^{[1
]}

机构：

[1] Univ Wurzburg, Univ Klinikum, Med Klin 1, D-97080 Wurzburg, Germany

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 35卷 / 07期

关键词：

cardiac repair; heart failure; left ventricular remodelling; myocardial infarction; stem cell transplantation;

D O I：

10.1111/j.1365-2362.2005.01510.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent experimental and clinical trials give rise to the hope that progenitor cells could replace scar tissue after myocardial infarction with healthy functional myocardium. However, while a significant increase in left ventricular ejection fraction has been described after progenitor cell transplantation in several clinical trials, long-term results are lacking, and the mechanisms underlying the improvement of ejection fraction are unclear. Therefore, the efficacy of progenitor cell transplantation after myocardial infarction has not been established, and potential problems may have been underestimated. In-depth laboratory and animal studies are needed to determine the best cell type, optimal amount of cells, and time point for transplantation. Treatment of patients with progenitor cells outside well controlled prospective trials should be avoided.

引用

页码：417 / 420

页数：4

共 31 条

[1] Comparison of human skeletal myoblasts and bone marrow-derived CD133+ progenitors for the repair of infarcted myocardium [J].

Agbulut, O ;

Vandervelde, S ;

Al Attar, N ;

Larghero, J ;

Ghostine, S ;

Léobon, B ;

Robidel, E ;

Borsani, P ;

Le Lorc'h, M ;

Bissery, A ;

Chomienne, C ;

Bruneval, P ;

Marolleau, JP ;

Vilquin, JT ;

Hagège, A ;

Samuel, JL ;

Menasché, P .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 44 (02) :458-463

[2] Myocyte renewal and ventricular remodelling [J].

Anversa, P ;

Nadal-Ginard, B .

NATURE, 2002, 415 (6868) :240-243

[3] Transplantation of autologous fresh bone marrow into infarcted myocardium:: A word of caution [J].

Bel, A ;

Messas, E ;

Agbulut, O ;

Richard, P ;

Samuel, JL ;

Bruneval, P ;

Hagège, AA ;

Menasché, P .

CIRCULATION, 2003, 108 (10) :247-252

[4] Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction [J].

Chen, SL ;

Fang, W ;

Ye, F ;

Liu, YH ;

Qian, J ;

Shan, S ;

Zhang, J ;

Zhao, RCH ;

Liao, LM ;

Lin, S ;

Sun, JP .

AMERICAN JOURNAL OF CARDIOLOGY, 2004, 94 (01) :92-95

[5] Hematopoietic stem cells do not repair the infarcted mouse heart [J].

Deten, A ;

Volz, HC ;

Clamors, S ;

Leiblein, S ;

Briest, W ;

Marx, G ;

Zimmer, HG .

CARDIOVASCULAR RESEARCH, 2005, 65 (01) :52-63

[6] Healing after myocardial infraction [J].

Ertl, G ;

Frantz, S .

CARDIOVASCULAR RESEARCH, 2005, 66 (01) :22-32

[7] Autotransplantation of unmanipulated bone marrow into scarred myocardium is safe and enhances cardiac function in humans [J].

Galiñanes, M ;

Loubani, M ;

Davies, J ;

Chin, D ;

Pasi, J ;

Bell, PR .

CELL TRANSPLANTATION, 2004, 13 (01) :7-13

[8] Time course of cardiac structural, functional and electrical changes in asymptomatic patients after myocardial infarction: Their inter-relation and prognostic impact [J].

Gaudron, P ;

Kugler, I ;

Hu, K ;

Bauer, W ;

Eilles, C ;

Ertl, G .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (01) :33-40

[9] c-kit-Immunopositive vascular progenitor cells populate human coronary in-stent restenosis but not primary atherosclerotic lesions [J].

Hibbert, B ;

Chen, YX ;

O'Brien, ER .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (02) :H518-H524

[10] Effect of prolonged inotropic stimulation on ventricular remodeling during healing after myocardial infarction in the dog: Mechanistic insights [J].

Jugdutt, BI ;

Khan, MI ;

Jugdutt, SJ ;

Blinston, GE .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 27 (07) :1787-1795

← 1 2 3 4 →