Novel antioxidants in anthracycline cardiotoxicity

被引：27

作者：

Hideg, Kalman ^{[1
]}

Kalai, Tamas ^{[1
]}

机构：

[1] Univ Pecs, Dept Organ & Med Chem, H-7602 Pecs, Hungary

来源：

CARDIOVASCULAR TOXICOLOGY | 2007年 / 7卷 / 02期

关键词：

anthracyclines; antioxidants; cardiomyopathy; EPR; free radicals; nitroxides;

D O I：

10.1007/s12012-007-0019-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been suggested nitroxides and their amine precursors prevent incidence of damage caused by superoxide and hydroxyl radicals formed during the oxidative metabolism of doxorubicin (DOX) and daunorubicin (DAU). Both doxorubicin and daunorubicin have been associated with cardiac toxicity in both adults and children. The authors herein suggest that cardioprotective molecules modified by nitroxides and their secondary amine precursors can prevent or diminish the anthracycline-induced cardiomyopathy by accumulating in cardiomiocytes.

引用

页码：160 / 164

页数：5

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