3β-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect

被引：72

作者：

Yasukawa, K

Kaminaga, T

Kitanaka, S

Tai, T

Nunoura, Y

Natori, S

Takido, M

机构：

[1] Nihon Univ, Coll Pharm, Funabashi, Chiba 274, Japan

[2] Kotaro Pharmaceut Co Ltd, Cent Res Lab, Takatsuki, Osaka 569, Japan

[3] Meiji Coll Pharm, Tanashi, Tokyo 188, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 48卷 / 08期

关键词：

Poria cocos; Polyporaceae; triterpene; 3 beta-p-hydroxybenzoyldehydrotumulosic acid; anti-inflammatory effect; TPA-induced inflammation; arachidonic acid-induced; inflammation;

D O I：

10.1016/S0031-9422(97)01063-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of a new triterpene derivative isolated from Poria cocos was determined to be 3 beta-p-hydroxybenzoyldehydrotumulosic acid by spectral and chemical methods. 3 beta-p-hydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)and arachidonic acid (AA)-induced ear inflammation in mice. The 50% inhibitory doses of 3 beta-p-hydroxybenzoyldehydrotumulosic acid were 0.27 and 1.25 mg per ear on TPA- and AA-induced inflammation, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1357 / 1360

页数：4

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